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Deciphering the molecular landscape of the FAM72 gene family: Implications for stem cell biology and cancer

Authors
Ramesh, JananiGopalakrishnan, Raja MohanNguyen, Tuan Hoang AnhLai, Soak-KuanLi, Hoi-YeungKim, Pok-SonKutzner, ArneInoue, NorikoHeese, Klaus
Issue Date
Nov-2024
Publisher
Elsevier Ltd
Keywords
Cell cycle; DNA repair; FOXM1; Glioblastoma; Proliferation; Stem cell; UNG
Citation
Neurochemistry International, v.180, pp 1 - 13
Pages
13
Indexed
SCIE
SCOPUS
Journal Title
Neurochemistry International
Volume
180
Start Page
1
End Page
13
URI
https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/212019
DOI
10.1016/j.neuint.2024.105853
ISSN
0197-0186
1872-9754
Abstract
Family with sequence similarity 72 (FAM72) is a protein-coding gene family located on chromosome 1 in humans, uniquely featuring four paralogs: FAM72A, FAM72B, FAM72C, and FAM72D. While FAM72's presence as a gene pair with the SLIT-ROBO Rho GTPase-activating protein 2 (SRGAP2) is intriguing, its functional roles, particularly in neural stem cells, remain incompletely understood. This review explores the distinct characteristics of FAM72, shedding light on its expression patterns, potential roles in cell cycle regulation, stem cell renewal and implications in neurogenesis and tumorigenesis.
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