Late-onset systemic lupus erythematosus: Is it "mild lupus"?
- Authors
- Sohn, I. W.; Joo, Y. B.; Won, S.; Bae, S. C.
- Issue Date
- Feb-2018
- Publisher
- SAGE PUBLICATIONS LTD
- Keywords
- Systemic lupus erythematosus; late-onset; prognosis
- Citation
- LUPUS, v.27, no.2, pp.235 - 242
- Indexed
- SCIE
SCOPUS
- Journal Title
- LUPUS
- Volume
- 27
- Number
- 2
- Start Page
- 235
- End Page
- 242
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/2418
- DOI
- 10.1177/0961203317716789
- ISSN
- 0961-2033
- Abstract
- Objective
The objective of this paper is to investigate the clinical characteristics and prognosis of patients with late-onset systemic lupus erythematosus (SLE) using a prospective observational cohort.
Methods
Late-onset SLE (≥50 years old) was compared with adult-onset SLE (≥18 and <50 years old) using 1997 ACR classification criteria for SLE, autoantibodies, disease activity measured by Adjusted Mean SLE Disease Activity Index (AMS), and damage measured by Systemic Lupus International Collaborating Clinics/ACR Damage Index (SDI). The standardized mortality ratio (SMR) was calculated.
Results
A total of 917 patients with SLE were enrolled. The mean number of cumulative ACR criteria in late-onset SLE (n = 32, 3.5%) was lower than that in adult-onset SLE (4.6 ± 1.2 vs. 5.5 ± 1.4, p < 0.05). The percentage of patients with low complement was lower in late-onset SLE than adult-onset SLE (p < 0.05). AMS was also lower in late-onset SLE (2.7 ± 2.1 vs. 4.3 ± 2.6, p < 0.01), but SDI was similar between the two groups (50% vs. 43.4%, p = 0.58). The SMR of late-onset SLE was 1.58 (95% CI 0.58–3.43), while the SMR of adult-onset SLE was 3.34 (2.34–4.63).
Conclusion
Compared with adult-onset SLE, late-onset SLE has a lower number of ACR criteria and lower disease activity. Organ damage is not different, but prognosis and mortality are more favorable.
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