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A novel peptide-based recognition probe for the sensitive detection of CD44 on breast cancer stem cells
- Issue Date
- Dec-2015
- Publisher
- ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
- Keywords
- CD44; Breast cancer stem cell; Peptide; PDPP
- Citation
- MOLECULAR AND CELLULAR PROBES, v.29, no.6, pp.492 - 499
- Indexed
- SCIE
SCOPUS
- Journal Title
- MOLECULAR AND CELLULAR PROBES
- Volume
- 29
- Number
- 6
- Start Page
- 492
- End Page
- 499
- ISSN
- 0890-8508
- Abstract
- Metastasis and recurrence of breast cancer remain significant clinical problems. The expression level of CD44 protein is higher in breast cancer-initiating cancer stem cells; therefore, the early detection of CD44 using a sensitive diagnostic probe is important for breast cancer diagnosis and therapeutic purposes. In this study, we fabricated a polyvalent directed peptide polymer (PDPP) that specifically recognized the CD44 biomarker, as confirmed by immunocytochemistry tests and fluorescence-activated cell sorting assessment. Our results indicate that PDPP is useful as a novel tool for the sensitive detection of breast cancer stem cells. (C) 2015 Elsevier Ltd. All rights reserved.
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