FCGR2A, FCGR3A, FCGR3B polymorphisms and susceptibility to rheumatoid arthritis: a meta-analysis
- Authors
- Lee, Y. H.; Bae, S. -C.; Song, G. G.
- Issue Date
- Sep-2015
- Publisher
- CLINICAL & EXPER RHEUMATOLOGY
- Keywords
- FCG receptor; polymorphism; rheumatoid arthritis; meta-analysis
- Citation
- CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, v.33, no.5, pp.647 - 654
- Indexed
- SCIE
SCOPUS
- Journal Title
- CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
- Volume
- 33
- Number
- 5
- Start Page
- 647
- End Page
- 654
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/24873
- ISSN
- 0392-856X
- Abstract
- Objective
The aim of this study is to explore whether Fc gamma receptor (FCGR) polymorphisms are associated with the susceptibility to rheumatoid arthritis (RA).
Methods
We conducted a meta-analysis on the association between FCGR2A H131R (rs1801274), FCGR3A F158V (rs396991), and FCGR3B NA1INA2 polymorphisms and RA susceptibility
Results
A total of seventeen studies reported in fourteen articles (4,418 patients with RA and 3,560 controls) were considered in our meta-analysis. In all of the study subjects, meta-analysis indicated an association between RA and FCGR2A R allele (OR=0.877, 95% CI=0.792-0.971, p=0.011). Stratification by ethnicity indicated an association between FCGR2A R allele and RA in Europeans (OR=0.816, 95% CI=0.687-0.968, p=0.020), but not in East Asians (OR=0.900, 95% CI=0.778-1.040, p=0.154). Meta-analysis revealed an association between RA and FCGR3A VV vs. FF genotype in all the study subjects (OR=1.210, 95% CI=1.067-1.479, p=0.006). Stratification by ethnicity indicated an association between FCGR3A VV genotype and RA compared to FF genotype in Europeans (OR=1.350, 95% CI=1.107-1.646, p=0.003), but not in East Asians and South Asians. No association was observed between RA and FCGR3B polymorphisms on performing the meta-analysis.
Conclusion
Although no relationship was found between the FCGR3B polymorphism and RA susceptibility, FCGR2A and FCGR3A polymorphisms were found to be associated With RA in Europeans, but not in Asians.
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