Anti-C1q antibodies in systemic lupus erythematosusopen access
- Authors
- Orbai, A-M; Truedsson, L.; Sturfelt, G.; Nived, O.; Fang, H.; Alarcon, G. S.; Gordon, C.; Merrill, J. T.; Fortin, P. R.; Bruce, I. N.; Isenberg, D. A.; Wallace, D. J.; Ramsey-Goldman, R.; Bae, S-C; Hanly, J. G.; Sanchez-Guerrero, J.; Clarke, A. E.; Aranow, C. B.; Manzi, S.; Urowitz, M. B.; Gladman, D. D.; Kalunian, K. C.; Costner, M. I.; Werth, V. P.; Zoma, A.; Bernatsky, S.; Ruiz-Irastorza, G.; Khamashta, M. A.; Jacobsen, S.; Buyon, J. P.; Maddison, P.; Dooley, M. A.; Van Vollenhoven, R. F.; Ginzler, E.; Stoll, T.; Peschken, C.; Jorizzo, J. L.; Callen, J. P.; Lim, S. S.; Fessler, B. J.; Inanc, M.; Kamen, D. L.; Rahman, A.; Steinsson, K.; Franks, A. G., Jr.; Sigler, L.; Hameed, S.; Pham, N.; Brey, R.; Weisman, M. H.; McGwin, G., Jr.; Magder, L. S.; Petri, M.
- Issue Date
- Jan-2015
- Publisher
- SAGE PUBLICATIONS LTD
- Keywords
- Anti-dsDNA antibodies; renal lupus; systemic lupus erythematosus
- Citation
- LUPUS, v.24, no.1, pp.42 - 49
- Indexed
- SCIE
SCOPUS
- Journal Title
- LUPUS
- Volume
- 24
- Number
- 1
- Start Page
- 42
- End Page
- 49
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/25661
- DOI
- 10.1177/0961203314547791
- ISSN
- 0961-2033
- Abstract
- Objective
Anti-C1q has been associated with systemic lupus erythematosus (SLE) and lupus nephritis in previous studies. We studied anti-C1q specificity for SLE (vs rheumatic disease controls) and the association with SLE manifestations in an international multicenter study.
Methods
Information and blood samples were obtained in a cross-sectional study from patients with SLE (n = 308) and other rheumatologic diseases (n = 389) from 25 clinical sites (84% female, 68% Caucasian, 17% African descent, 8% Asian, 7% other). IgG anti-C1q against the collagen-like region was measured by ELISA.
Results
Prevalence of anti-C1q was 28% (86/308) in patients with SLE and 13% (49/389) in controls (OR = 2.7, 95% CI: 1.8–4, p < 0.001). Anti-C1q was associated with proteinuria (OR = 3.0, 95% CI: 1.7–5.1, p < 0.001), red cell casts (OR = 2.6, 95% CI: 1.2–5.4, p = 0.015), anti-dsDNA (OR = 3.4, 95% CI: 1.9–6.1, p < 0.001) and anti-Smith (OR = 2.8, 95% CI: 1.5–5.0, p = 0.01). Anti-C1q was independently associated with renal involvement after adjustment for demographics, ANA, anti-dsDNA and low complement (OR = 2.3, 95% CI: 1.3–4.2, p < 0.01). Simultaneously positive anti-C1q, anti-dsDNA and low complement was strongly associated with renal involvement (OR = 14.9, 95% CI: 5.8–38.4, p < 0.01).
Conclusions
Anti-C1q was more common in patients with SLE and those of Asian race/ethnicity. We confirmed a significant association of anti-C1q with renal involvement, independent of demographics and other serologies. Anti-C1q in combination with anti-dsDNA and low complement was the strongest serological association with renal involvement. These data support the usefulness of anti-C1q in SLE, especially in lupus nephritis.
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