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Doxycycline Enhances Survival and Self-Renewal of Human Pluripotent Stem Cells
- Authors
- Chang, Mi-Yoon; Rhee, Yong-Hee; Yi, Sang-Hoon; Lee, Su-Jae; Kim, Rae-Kwon; Kim, Hyongbum; Park, Chang-Hwan; Lee, Sang-Hun
- Issue Date
- Aug-2014
- Publisher
- Cell Press
- Citation
- Stem Cell Reports, v.3, no.2, pp 353 - 364
- Pages
- 12
- Indexed
- SCIE
SCOPUS
- Journal Title
- Stem Cell Reports
- Volume
- 3
- Number
- 2
- Start Page
- 353
- End Page
- 364
- ISSN
- 2213-6711
- Abstract
- We here report that doxycycline, an antibacterial agent, exerts dramatic effects on human embryonic stem and induced pluripotent stem cells (hESC/iPSCs) survival and self-renewal. The survival-promoting effect was also manifest in cultures of neural stem cells (NSCs) derived from hESC/iPSCs. These doxycycline effects are not associated with its antibacterial action, but mediated by direct activation of a PI3K-AKT intracellular signal. These findings indicate doxycycline as a useful supplement for stem cell cultures, facilitating their growth and maintenance.
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