Gene-environmental interaction between smoking and shared epitope on the development of anti-cyclic citrullinated peptide antibodies in rheumatoid arthritis: a meta-analysisopen access
- Authors
- Lee, Young Ho; Bae, Sang-Cheol; Song, Gwan Gyu
- Issue Date
- Jun-2014
- Publisher
- WILEY
- Keywords
- anti-CCP antibodies; rheumatoid arthritis; shared epitope; smoking
- Citation
- INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES, v.17, no.5, pp.528 - 535
- Indexed
- SCIE
SCOPUS
- Journal Title
- INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
- Volume
- 17
- Number
- 5
- Start Page
- 528
- End Page
- 535
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/25865
- DOI
- 10.1111/1756-185X.12307
- ISSN
- 1756-1841
- Abstract
- Objective
The aim of this study was to determine the gene–environment interactions of smoking and shared epitope (SE) both separately and combined on anti-cyclic citrullinated peptide (CCP) antibodies in patients with rheumatoid arthritis (RA).
Methods
The literature was searched using the MEDLINE, EMBASE and Cochrane databases. A meta-analysis on the associations between tobacco exposure (TE) and/or SE and the development of anti-CCP antibodies in patients with RA was performed.
Results
Eight comparison studies with 5317 RA patients were considered in this meta-analysis. The odds ratio (OR) for positive anti-CCP antibodies in TE+/SE− patients with RA was increased compared with TE−/SE− patients (OR = 1.373, 95% CI = 1.111–1.698, P = 0.003). The ORs for positive anti-CCP antibodies in TE−/SE+ patients and TE+/SE+ patients with RA were also increased compared with TE−/SE− patients (OR = 2.678, 95% CI = 2.031–3.532, P < 1.0 × 10−9 in TE−/SE+; OR = 4.233, 95% CI = 2.458–7.291, P = 1.9 × 10−8 in TE+/SE+). Stratification by ethnicity indicated the same pattern as that shown in the overall group. The OR for positive anti-CCP antibodies in TE+/SE+ patients with RA was much higher than in TE−/SE− patients in Europeans and Asians (OR = 3.879, 95% CI = 2.203–6.830, P = 2.6 × 10−7; OR = 10.504, 95% CI = 3.182–34.67, P = 1.1 × 10−4).
Conclusions
This meta-analysis suggests a gene–environmental interaction between smoking and SE for the development of anti-CCP antibodies.
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