Fractionated radiation-induced nitric oxide promotes expansion of glioma stem-like cellsopen access
- Authors
- Kim, Rae-Kwon; Suh, Yongjoon; Cui, Yan-Hong; Hwang, Eunji; Lim, Eun-Jung; Yoo, Ki-Chun; Lee, Ga-Haeng; Yi, Joo-Mi; Kang, Seok-Gu; Lee, Su-Jae
- Issue Date
- Sep-2013
- Publisher
- WILEY
- Citation
- CANCER SCIENCE, v.104, no.9, pp.1172 - 1177
- Indexed
- SCIE
SCOPUS
- Journal Title
- CANCER SCIENCE
- Volume
- 104
- Number
- 9
- Start Page
- 1172
- End Page
- 1177
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/26659
- DOI
- 10.1111/cas.12207
- ISSN
- 1347-9032
- Abstract
- Glioblastoma remains an incurable brain disease due to the prevalence of its recurrence. Considerable evidence suggests that glioma stem-like cells are responsible for glioma relapse after treatment, which commonly involves ionizing radiation. Here, we found that fractionated ionizing radiation (2Gy/day for 3days) induced glioma stem-like cell expansion and resistance to anticancer treatment such as cisplatin (50M) or taxol (500nM), or by ionizing radiation (10Gy) in both glioma cell lines (U87, U373) and patient-derived glioma cells. Of note, concomitant increase of nitric oxide production occurred with the radiation-induced increase of the glioma stem-like cell population through upregulation of inducible nitric oxide synthase (iNOS). In line with this observation, downregulation of iNOS effectively reduced the glioma stem-like cell population and decreased resistance to anticancer treatment. Collectively, our results suggest that targeting iNOS in combination with ionizing radiation might increase the efficacy of radiotherapy for glioma treatment.
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