Detailed Information

Cited 33 time in webofscience Cited 35 time in scopus
Metadata Downloads

Fractionated radiation-induced nitric oxide promotes expansion of glioma stem-like cellsopen access

Authors
Kim, Rae-KwonSuh, YongjoonCui, Yan-HongHwang, EunjiLim, Eun-JungYoo, Ki-ChunLee, Ga-HaengYi, Joo-MiKang, Seok-GuLee, Su-Jae
Issue Date
Sep-2013
Publisher
WILEY
Citation
CANCER SCIENCE, v.104, no.9, pp.1172 - 1177
Indexed
SCIE
SCOPUS
Journal Title
CANCER SCIENCE
Volume
104
Number
9
Start Page
1172
End Page
1177
URI
https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/26659
DOI
10.1111/cas.12207
ISSN
1347-9032
Abstract
Glioblastoma remains an incurable brain disease due to the prevalence of its recurrence. Considerable evidence suggests that glioma stem-like cells are responsible for glioma relapse after treatment, which commonly involves ionizing radiation. Here, we found that fractionated ionizing radiation (2Gy/day for 3days) induced glioma stem-like cell expansion and resistance to anticancer treatment such as cisplatin (50M) or taxol (500nM), or by ionizing radiation (10Gy) in both glioma cell lines (U87, U373) and patient-derived glioma cells. Of note, concomitant increase of nitric oxide production occurred with the radiation-induced increase of the glioma stem-like cell population through upregulation of inducible nitric oxide synthase (iNOS). In line with this observation, downregulation of iNOS effectively reduced the glioma stem-like cell population and decreased resistance to anticancer treatment. Collectively, our results suggest that targeting iNOS in combination with ionizing radiation might increase the efficacy of radiotherapy for glioma treatment.
Files in This Item
Appears in
Collections
서울 자연과학대학 > 서울 생명과학과 > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Altmetrics

Total Views & Downloads

BROWSE