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Phage Display Screen for Peptides That Bind Bcl-2 Proteinopen access
- Authors
- Park, Hye-Yeon; Kim, Joungmok; Cho, June-Haeng; Moon, Ji Young; Lee, Su-Jae; Yoon, Moon-Young
- Issue Date
- Jan-2011
- Publisher
- SAGE PUBLICATIONS INC
- Keywords
- cancer; apoptosis; diagnostics probe; Bcl-2 protein-binding peptides; M13 phage display
- Citation
- JOURNAL OF BIOMOLECULAR SCREENING, v.16, no.1, pp.82 - 89
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF BIOMOLECULAR SCREENING
- Volume
- 16
- Number
- 1
- Start Page
- 82
- End Page
- 89
- ISSN
- 1087-0571
- Abstract
- Bcl-2 family proteins are key regulators of apoptosis associated with human disease, including cancer. Bcl-2 protein has been found to be overexpressed in many cancer cells. Therefore, Bcl-2 protein is a potential diagnostic target for cancer detection. In the present study, the authors have identified several Bcl-2 binding peptides with high affinity (picomolar range) from a 5-round M13 phage display library screening. These peptides can be used to develop novel diagnostic probes or potent inhibitors with diverse polyvalencies. (Journal of Biomolecular Screening 2011:82-89)
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