Genomic alterations of ground-glass nodular lung adenocarcinomaopen access
- Authors
- Lee, Hyun; Joung, Je-Gun; Shin, Hyun-Tae; Kim, Duk-Hwan; Kim, Yujin; Kim, Hojoong; Kwon, O. Jung; Shim, Young Mog; Lee, Ho Yun; Lee, Kyung Soo; Choi, Yoon-La; Park, Woong-Yang; Hayes, D. Neil; Um, Sang-Won
- Issue Date
- Dec-2018
- Publisher
- Nature Publishing Group
- Citation
- Scientific Reports, v.8, no.1, pp.1 - 9
- Indexed
- SCIE
SCOPUS
- Journal Title
- Scientific Reports
- Volume
- 8
- Number
- 1
- Start Page
- 1
- End Page
- 9
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/3294
- DOI
- 10.1038/s41598-018-25800-2
- ISSN
- 2045-2322
- Abstract
- In-depth molecular pathogenesis of ground-glass nodular lung adenocarcinoma has not been well understood. The objectives of this study were to identify genomic alterations in ground-glass nodular lung adenocarcinomas and to investigate whether viral transcripts were detected in these tumors. Nine patients with pure (n = 4) and part-solid (n = 5) ground-glass nodular adenocarcinomas were included. Six were females with a median age of 58 years. We performed targeted exon sequencing and RNA sequencing. EGFR (n = 10), IDH2 (n = 2), TP53 (n = 1), PTEN (n = 1), EPHB4 (n = 1), and BRAF (n = 1) were identified as driver mutations by targeted exon sequencing. Vasculogenesis-associated genes including NOTCH4 and TGFBR3 expression were significantly downregulated in adenocarcinoma tissue versus normal tissue (adjusted P values ˂ 0.001 for both NOTCH4 and TGFBR3). In addition, five novel fusion gene loci were identified in four lung adenocarcinomas. However, no significant virus-associated transcripts were detected in tumors. In conclusions, EGFR, IDH2, TP53, PTEN, EPHB4, and BRAF were identified as putative driver mutations of ground-glass nodular adenocarcinomas. Five novel fusion genes were also identified in four tumors. Viruses do not appear to be involved in the tumorigenesis of ground-glass nodular lung adenocarcinoma.
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