Association between metabolic parameters and glomerular hyperfiltration in a representative Korean population without chronic kidney diseaseopen access
- Authors
- Hong, Sang mo; Choi Y.M.; Ihm S.-H.; Kim D.; Choi M.-G.; Yu J.M.; Hong E.-G.
- Issue Date
- Dec-2018
- Publisher
- PUBLIC LIBRARY SCIENCE
- Citation
- PLOS ONE, v.13, no.12
- Indexed
- SCIE
SCOPUS
- Journal Title
- PLOS ONE
- Volume
- 13
- Number
- 12
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/3295
- DOI
- 10.1371/journal.pone.0207843
- ISSN
- 19326203
- Abstract
- Aims
To investigate associations of glomerular hyperfiltration with other metabolic factors in a nationally representative dataset.
Methods
We analyzed cross-sectional data from 15,918 subjects with estimated glomerular filtration rate (eGFR) >60 ml/min/1.73 m2 and urine albumin creation ratio (ACR) <30 mg/g, who participated in the 5th and 6th Korea National Health and Nutrition Examination Surveys. Hyperfiltration was defined as eGFR (CKD-EPI equation) exceeding the age- and sex-specific 95th percentile for healthy control subjects.
Results
Prevalence of hyperfiltration was 5.2% and that among normal, prediabetic, and diabetic subjects was 4.9%, 5.6%, and 7.3%, respectively, after adjusting for age, sex, and body weight (p for trend = 0.008). In a multiple logistic regression analysis, hyperfiltration was associated with a body mass index ≥30 kg/m2 [odds ratio (OR) = 3.461, p<0.001], waist circumference 85 cm (men) or 80 cm (women) (OR = 1.425, p = 0.015), systolic blood pressure 120–129 mmHg (OR = 1.644, p = 0.022), fasting plasma glucose 140 mg/dL (OR = 1.695, p = 0.033) and t serum triglyceride level 500 mg/dL (OR = 2.988, p = 0.001), and was independently associated with the ACR (B = 0.053, p<0.001).
Conclusions
In a general Korean population, both hyperfiltration and ACR were associated with similar metabolic parameters, and hyperfiltration correlated independently with a high ACR. Longitudinal studies are needed to further explore risks of hyperfiltration and microalbuminuria.
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