The effectiveness of transarterial chemoembolization in recurrent hepatocellular-cholangiocarcinoma after resectionopen access
- Authors
- Na, S.K.; Choi, G.H.; Lee, H.C.; Shin, Y.M.; An, Ji hyun; Lee, D.; Shim, J.H.; Kim, K.M.; Lim, Y.-S.; Chung, Y.-H.; Lee, Y.S.
- Issue Date
- Jun-2018
- Publisher
- PUBLIC LIBRARY SCIENCE
- Citation
- PLOS ONE, v.13, no.6, pp.1 - 2
- Indexed
- SCIE
SCOPUS
- Journal Title
- PLOS ONE
- Volume
- 13
- Number
- 6
- Start Page
- 1
- End Page
- 2
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/3337
- DOI
- 10.1371/journal.pone.0198138
- ISSN
- 1932-6203
- Abstract
- Background
Combined hepatocellular-cholangiocarcinoma (cHCC-CC) can present as a hypervascular or peripherally enhancing tumor in dynamic imaging. We evaluated the effect of transarterial chemoembolization (TACE) on prognosis according to post-operative recurrence imaging patterns.
Methods
We retrospectively analyzed 42 cHCC-CC and 59 hepatocellular carcinoma (HCC-control) patients at the Asan Medical Center. We classified recurrent cHCC-CC according to enhancement pattern (globally enhancing: GE cHCC-CC, peripherally enhancing: PE cHCC-CC) and evaluated tumor response, time-to-local progression (TTPlocal), and overall survival (OS).
Results
The GE cHCC-CC group had a significantly higher best objective response rate (complete remission + partial response) than the PE cHCC-CC group (36% vs 0%, P= 0.005), and it was comparable to that of the HCC-control group (35.6%, P= 0.97). TTPlocal in the GE cHCC-CC group was significantly shorter than in the HCC-control group (6.6 vs 27.1 months, P ˂ 0.001), and was not significantly different from that in the PE cHCC-CC group (5.3 months, P= 0.12). OS was 12.4 months, 52.8 months, and 67.5 months in the PE cHCC-CC, GE cHCC-CC, and HCC-control groups, respectively (Ps ˂ 0.05). The adjusted hazard ratios (HRs) for TTPlocal and OS revealed an independent association with enhancement pattern of recurrent cHCC-CC (TTPlocal: HR 2.46; 95% CI 1.10-5.46; P= 0.03; OS: HR 5.97; 95% CI 2.38-14.96; P˂ 0.001).
Conclusions
The GE cHCC-CC group showed better response and prognosis after TACE than the PE cHCC-CC group, but poorer response and prognosis than the HCC-control group. Enhancement patterns at recurrence were crucially associated with tumor response and overall survival.
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