Impact of edaphic factors and nutrient management on the hepatoprotective efficiency of Carlinoside purified from pigeon pea leaves: An evaluation of UGT1A1 activity in hepatitis induced organelles
- Authors
- Das, Subhasish; Teja, K. Charan; Mukherjee, Sandip; Seal, Soma; Sah, Rajesh Kumar; Duary, Buddhadeb; Kim, Ki-Hyun; Bhattacharya, Satya Sundar
- Issue Date
- Feb-2018
- Publisher
- ACADEMIC PRESS INC ELSEVIER SCIENCE
- Keywords
- Carlinoside; Cajanus cajan; Organic fertilization; Bilirubin solubilization; UGT1A1 expression
- Citation
- ENVIRONMENTAL RESEARCH, v.161, pp.512 - 523
- Indexed
- SCIE
SCOPUS
- Journal Title
- ENVIRONMENTAL RESEARCH
- Volume
- 161
- Start Page
- 512
- End Page
- 523
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/3399
- DOI
- 10.1016/j.envres.2017.11.054
- ISSN
- 0013-9351
- Abstract
- Carlinoside is a unique compound well-known for its excellent curative potential in hepatitis. There is a substantial research gap regarding the medicinal use of carlinoside, as its concentrations are greatly variable (depending on locality). We cultivated Cajanus cajan using vermicompost as a major organic amendment at two locations (Sonitpur and Birbhum) with different soil types, but identical climate conditions. Sonitpur soils were richer in soil organic C (SOC), enzyme activation, and N/P content than Birbhum. However, venni-treatment improved many soil properties (bulk density, water retention, pH, N/P/K, and enzyme activity) to narrow the locational gap in soil quality by 15-28%. We also recorded a many-fold increment in SOC storage capacities in both locations, which was significantly correlated with carlinoside, total phenol, and flavonoid contents in Cajanus leaves. This significantly up-regulated the carlinoside induced expression of the bilirubin-solubilizing UGT1A1enzyme in HepG2 cell and rat liver. Leaf extracts of vermicompost-aided plants could cure hepatitis in affected rat livers and in the HepG2 cell line. Accordingly, vermi-treatment is an effective route for the growth of Cajanus as a cash crop for biomedical applications and can produce a concurrent improvement in soil quality.
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