Influence of age at diagnosis on the clinical characteristics of Crohn's disease in Korea: Results from the CONNECT studyopen access
- Authors
- Hwang, Sung Wook; Kim, Jee Hyun; Im, Jong Pil; Ye, Byong Duk; Koo, Hoon Sup; Huh, Kyu Chan; Cheon, Jae Hee; Kim, You Sun; Kim, Young Ho; Han, Dong Soo; Kim, Won Ho; Kim, Joo Sung
- Issue Date
- Oct-2017
- Publisher
- WILEY
- Keywords
- age at diagnosis; Crohn' s disease; intestinal resection; medication
- Citation
- JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, v.32, no.10, pp.1716 - 1722
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
- Volume
- 32
- Number
- 10
- Start Page
- 1716
- End Page
- 1722
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/4047
- DOI
- 10.1111/jgh.13775
- ISSN
- 0815-9319
- Abstract
- Background and Aim
The present study evaluated the clinical characteristics of Korean patients with Crohn's disease (CD) according to their age at diagnosis in a nationwide multicenter cohort study.
Methods
A total of 1224 patients diagnosed with CD between 1982 and 2008 in 32 hospitals were included, and age at diagnosis was categorized as ≤ 16 (G1), 17–40 (G2), 41–59 (G3) and ≥ 60 (G4) years old. The baseline characteristics, medication, and intestinal resection were compared according to the age at diagnosis.
Results
The number of patients in each age group was 155 (G1; 12.7%), 919 (G2; 75.1%), 120 (G3; 9.8%), and 30 (G4; 2.5%). The frequencies of ileocolonic disease in the late adult onset and elderly onset groups were lower than those in the other groups (P < 0.001). The cumulative probabilities of thiopurine and anti-tumor necrosis factor use in late adult onset and elderly onset groups were significantly reduced compared with those of the other groups (P < 0.01). However, the risk of the first intestinal resection was not different among the age groups. The ileal location (hazard ratio [HR]: 1.59; 95% confidence interval [CI]: 1.11–2.27), complicated behavior (HR: 3.35; 95% CI: 2.63–4.27), and early thiopurine use (HR: 0.27; 95% CI: 0.17–0.43) were associated with the first intestinal resection, whereas the age at diagnosis was not a risk factor.
Conclusions
Elderly onset CD may be related to favorable outcomes in Korea. Thus, the heterogeneity of this disease should be considered when developing a tailored strategy for the treatment of CD.
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