Effect of Relaxin Expressing Adenovirus on Scar Remodeling: A Preliminary Studyopen access
- Authors
- 정복기; 이원재; 강은혜; 안효민; 김용욱; 나동균; 윤채옥; 윤인식
- Issue Date
- Mar-2017
- Publisher
- 대한두개안면성형외과학회
- Keywords
- Gene therapy; Cicatrix; Relaxin; Adenovirus
- Citation
- Archives of Craniofacial Surgery, v.18, no.1, pp.9 - 15
- Indexed
- KCI
OTHER
- Journal Title
- Archives of Craniofacial Surgery
- Volume
- 18
- Number
- 1
- Start Page
- 9
- End Page
- 15
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/4263
- DOI
- 10.7181/acfs.2017.18.1.9
- ISSN
- 2287-1152
- Abstract
- Background: Relaxin is a transforming growth factor β1 antagonist. To determine the effects of relaxin on scar reduction, we investigated the scar remodeling process by injecting relaxin-expressing adenoviruses using a pig scar model.
Methods: Scars with full thickness were generated on the backs of Yorkshire pigs. Scars were divided into two groups (relaxin [RLX] and Control). Adenoviruses were injected into the RLX (expressing relaxin) and Control (not expressing relaxin) groups. Changes in the surface areas, color index and pliability of scars were compared.
Results: Fifty days after treatment, the surface areas of scars decreased, the color of scars was normalized, and the pliability of scars increased in RLX group.
Conclusion: Relaxin-expressing adenoviruses improved the surface area, color, and pliability of scars. The mechanism of therapeutic effects on scar formation should be further investigated.
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