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Synthesis and biological evaluation of acylthiourea against DUSP1 inhibition
- Authors
- Kim, Bo Yeon; Yoon, Ji Hee; Kim, Myeongbin; Kim, Jae Nyoung; Park, Hwangseo; Ryu, Seong Eon; Lee, Sangku
- Issue Date
- Jul-2019
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- Dual specificity phosphatase; Mitogen-activated protein kinase; Enzyme inhibition; Structure activity relationship; Cancer
- Citation
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.29, no.14, pp.1746 - 1748
- Indexed
- SCIE
SCOPUS
- Journal Title
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Volume
- 29
- Number
- 14
- Start Page
- 1746
- End Page
- 1748
- ISSN
- 0960-894X
- Abstract
- Structure based virtual screening attempts to discover DUSP1 inhibitors have yielded a scaffold featuring benzoxazole and acylthiourea pharmacophore. A series of its analogues were synthesized to explore structure activity relationship (SAR) of DUSP1 inhibition.
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Related Researcher
- Ryu, Seong Eon
- COLLEGE OF ENGINEERING (DEPARTMENT OF BIOENGINEERING)