RAGE-binding peptide-conjugated polyethylenimine as a dual-functional carrier: A RAGE-mediated gene carrier and an anti-angiogenic reagent
- Authors
- Lee, Dahee; Choi, Eunji; Lee, Jaewon; Oh, Jungju; Lee, Seonyeong; Lee, Minhyung
- Issue Date
- Nov-2018
- Publisher
- ELSEVIER SCIENCE INC
- Keywords
- Anti-angiogenesis; Gene delivery; Glioblastoma; Polyethylenimine; RAGE-binding peptide
- Citation
- JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY, v.67, pp.284 - 292
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
- Volume
- 67
- Start Page
- 284
- End Page
- 292
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/4660
- DOI
- 10.1016/j.jiec.2018.06.040
- ISSN
- 1226-086X
- Abstract
- Receptor for advanced glycation end-products (RAGE) is overexpressed in various cancer cells. In this study, a RAGE-binding peptide (RBP) was conjugated to polyethylenimine (25 kDa, PEI). RBP-conjugated PEI (PEI-RBP) was characterized as a dual-functional reagent, a RAGE-mediated gene carrier and an anti-angiogenic reagent. As a gene carrier, PEI-RBP had higher transfection efficiency to the C6 glioblastoma cells than PEI. As an anti-angiogenic reagent, the pEmpty/PEI-RBP complex reduced RAGE expression on the surface of the C6 glioblastoma cells. Also, the complex reduced the VEGF expression and tube formation of endothelial cells. Therefore, PEI-RBP may be useful for development of glioblastoma therapy.
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