Local Injection of Granulocyte-Colony Stimulating Factor Accelerates Wound Healing in a Rat Excisional Wound Model
- Authors
- Shen, Guang-Yin; Park, In-Hwa; Song, Yi-Sun; Joo, Hyun-Woo; Lee, Yonggu; Shin, Jeong-Hun; Kim, Kyung-Soo; Kim, Hyuck
- Issue Date
- Jun-2016
- Publisher
- KOREAN TISSUE ENGINEERING REGENERATIVE MEDICINE SOC
- Keywords
- Granulocyte-colony stimulating factor; Wound healing; Local injection
- Citation
- TISSUE ENGINEERING AND REGENERATIVE MEDICINE, v.13, no.3, pp.297 - 303
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- TISSUE ENGINEERING AND REGENERATIVE MEDICINE
- Volume
- 13
- Number
- 3
- Start Page
- 297
- End Page
- 303
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/5038
- DOI
- 10.1007/s13770-016-9054-9
- ISSN
- 1738-2696
- Abstract
- A systemic treatment of granulocyte-colony stimulating factor (G-CSF) is known to improve healings of damaged tissues. However, recent studies suggested local actions of G-CSF on the healing processes of damaged tissues. We investigated the treatment effect of locally injected G-CSF and compared to that of systemically injected G-CSF in a rat model. A wound was created on the rat dorsum and treated either by local injection or by systemic injection of G-CSF. Wound healing rate, deposition of collagen, and gene expression were evaluated. G-CSF receptor (G-CSFR) protein was detected by Western blotting. The wound healing rate in the local injection group was significantly higher than that in the systemic injection group at days 9 and 15; it was also significantly higher than that in the control group at days 3, 9, and 15. The expression of G-CSFR protein in wound tissues was higher than in normal skin tissues. The local injection of G-CSF is more effective than systemic injection of G-CSF in promoting wound healing, which may implicate the local action of G-CSF treatment in wound healing processes.
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