Enhancement of T2-weighted MR contrast using heparin for cell tracking in vivo
- Authors
- Hwang, Y.H.; Jeong, M.J.; Kim, M.J.; Kim, J.K.; Lee, D.Y.
- Issue Date
- Nov-2017
- Publisher
- Korean Society of Industrial Engineering Chemistry
- Keywords
- Cell transplantation; Cellular tracking; Heparin; MRI; Superparamagnetic iron oxide (SPIO)
- Citation
- Journal of Industrial and Engineering Chemistry, v.55, pp.183 - 190
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- Journal of Industrial and Engineering Chemistry
- Volume
- 55
- Start Page
- 183
- End Page
- 190
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/5365
- DOI
- 10.1016/j.jiec.2017.06.043
- ISSN
- 1226-086X
- Abstract
- Superparamagnetic iron oxide (SPIO) nanoparticle has emerged as a novel probe for noninvasively cellular tracking using magnetic resonance imaging. Here we developed SPIO nanoparticles coated with biocompatible heparins, i.e., low-molecular-weight-heparin (LMWH) or unfractionated heparin (UFH). These heparin-SPIO nanoparticles showed good crystallizability and stability without self-aggregation for 50 days. Also, UFH-SPIO nanoparticle had lower relaxation time with higher relaxivity. Moreover, they were efficiently internalized into cells without cytotoxicity and had faster saturated magnetization. Furthermore, the implanted SPIO nanoparticles-labeled Ins-1 cells were strongly visualized in vivo MR imaging. Collectively, heparin-based SPIO nanoparticles could have a great potential for in vivo cellular tracking.
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