Vitamin D Deficiency Is Associated with Rapid Decline in Exercise Capacity in Male Patients with Chronic Obstructive Pulmonary Disease
- Authors
- Kim, Changhwan; Jung, Ji Ye; Kim, Young Sam; Lee, Jae Seung; Rhee, Chin Kook; Lee, Jin Hwa; Lee, Ji-Hyun; Kim, Tae-Hyung; Lim, Seong Yong; Sheen, Seung Soo; Yoo, Kwang Ha; Seo, Joon Beom; Oh, Yeon-Mok; Lee, Sang-Do; Park, Yong Bum
- Issue Date
- Jun-2016
- Publisher
- KARGER
- Keywords
- Chronic obstructive pulmonary disease; Vitamin D deficiency; Exercise capacity; Six-minute walk distance
- Citation
- RESPIRATION, v.91, no.5, pp.351 - 358
- Indexed
- SCIE
SCOPUS
- Journal Title
- RESPIRATION
- Volume
- 91
- Number
- 5
- Start Page
- 351
- End Page
- 358
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/5579
- DOI
- 10.1159/000445266
- ISSN
- 0025-7931
- Abstract
- Background: Vitamin D is suggested to play a role in airway and systemic inflammation in chronic obstructive pulmonary disease (COPD). Low serum 25-hydroxyvitamin D (25-OHD) levels have been suggested to be associated with lower lung function and poorer exercise capacity in COPD.
Objectives: The main purpose of this study was to investigate the effects of vitamin D deficiency on the change in exercise capacity in male COPD patients.
Methods: A total of 156 male subjects were selected from the Korean Obstructive Lung Disease cohort. Vitamin D deficiency was subdivided into three subgroups: mild, moderate, and severe deficiency groups. Rapid decline was defined as an annual rate of change in exercise capacity ≥17 m. Exercise capacity was assessed by 6-minute walk distance (6MWD).
Results: Significant differences were observed in the serum levels of 25-OHD, the number of patients with vitamin D sufficiency, and moderate-to-severe deficiency between rapid decliners (n = 40) and non-rapid decliners (n = 116). No differences were found between the groups for age, smoking status, lung function, and 6MWD. Multivariate analysis showed that vitamin D deficiency was independently related to rapid decline in exercise capacity (p = 0.028). A statistically significant difference was observed among the subgroups of vitamin D deficiency in terms of the change in exercise capacity (p < 0.001). The annual decline in exercise capacity was prominent in the severe deficiency group (23.1 m/year).
Conclusion: This study shows that vitamin D deficiency is associated with rapid decline in exercise capacity in male patients with COPD.
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