Oxaliplatin-induced sinusoidal obstruction syndrome mimicking metastatic colon cancer in the liveropen access
- Authors
- Choi, Jung-Hye; Won, Young-Woong; Kim, Hyun Sung; Oh, Young-Ha; Lim, Sanghyeok; Kim, Han-Joon
- Issue Date
- Apr-2016
- Publisher
- SPANDIDOS PUBL LTD
- Keywords
- oxaliplatin; sinusoidal obstruction syndrome; colon cancer
- Citation
- ONCOLOGY LETTERS, v.11, no.4, pp.2861 - 2864
- Indexed
- SCIE
SCOPUS
- Journal Title
- ONCOLOGY LETTERS
- Volume
- 11
- Number
- 4
- Start Page
- 2861
- End Page
- 2864
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/5629
- DOI
- 10.3892/ol.2016.4286
- ISSN
- 1792-1074
- Abstract
- Oxaliplatin is an effective chemotherapeutic agent for the treatment of colorectal cancer; however, it may cause liver injury, particularly sinusoidal obstruction syndrome (SOS). Although SOS does not usually present with focal lesions on radiological images, the present study describes the case of a 22-year-old woman with oxaliplatin-induced SOS mimicking metastatic colon cancer in the liver. An abdominal computed tomography revealed a novel 1 cm, low-density lesion in segment 1 of the liver following the administration of the fourth round of oxaliplatin-based adjuvant chemotherapy for stage III colon cancer. Since the lesion was indistinguishable from metastasis, even with detailed imaging studies, including magnetic resonance imaging and positron emission tomography-computed tomography, an isolated caudate lobectomy was planned. The cut surface of the resected liver showed a localized reddish congested lesion measuring 1.4 cm in diameter. The adjacent hepatic parenchyma also demonstrated diffuse sinusoidal congestion with a nutmeg-like appearance. Histologically, the lesion exhibited severe sinusoidal congestion with peliosis hepatis-like features. The widened sinusoidal space was outlined by markedly attenuated hepatic cords and filled with erythrocytes. The final diagnosis was oxaliplatin-induced SOS. The patient recovered completely and was relapse-free at the time of writing.
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