A case of human immunodeficiency virus -triggered hemophagocytic lymphohistocytosis presenting with severe bleeding tendencyopen access
- Authors
- Kim, Bongyoung; Choi, Yeon Woo; Pai, Hyun joo; Kim, Jieun
- Issue Date
- Dec-2021
- Publisher
- Korean Society of Infectious Diseases, Korean Society for Antimicrobial Therapy, Korean Society for AIDS
- Keywords
- Acquired immune deficiency syndrome; Antiviral; Human immunodeficiency virus
- Citation
- Infection and Chemotherapy, v.53, no.1, pp.802 - 807
- Indexed
- SCOPUS
KCI
- Journal Title
- Infection and Chemotherapy
- Volume
- 53
- Number
- 1
- Start Page
- 802
- End Page
- 807
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/7965
- DOI
- 10.3947/IC.2018.0203
- ISSN
- 2093-2340
- Abstract
- Human immunodeficiency virus (HIV) is one of the less common triggers of secondary hemophagocytic lymphohistiocytosis (HLH) in which coagulation disorder is a frequent manifestation. Here, we present a case of HIV-triggered secondary HLH presenting with severe bleeding tendency and fever. Despite high-dose dexamethasone infusion (10 mg/body surface area/day), progressive disseminated intravascular coagulation and thrombocytopenia resulted in massive hemathochezia: the bleeding episode ceased after endoscopic hemoclipping. After then, he took a highly-active antiretroviral therapy (HAART). Eventually, body temperature and overall laboratory findings normalized in response to HAART. Clinicians should not overlook HIV infection as a possible trigger of secondary HLH. In such cases, HAART is the core treatment.
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