Association between insulin resistance and risk of atrial fibrillation in non-diabetics
- Authors
- Lee, Yonggu; Cha, Sung Joo; Park, Jung-Hwan; Shin, Jeong-Hun; Lim, Young-Hyo; Park, Hwan-Cheol; Shin, Jinho; Kim, Chun Ki; Park, Jin-Kyu
- Issue Date
- Dec-2020
- Publisher
- SAGE PUBLICATIONS LTD
- Keywords
- Insulin resistance; atrial fibrillation; obesity; epidemiology
- Citation
- EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY, v.27, no.18, pp.1934 - 1941
- Indexed
- SCIE
SCOPUS
- Journal Title
- EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
- Volume
- 27
- Number
- 18
- Start Page
- 1934
- End Page
- 1941
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/8181
- DOI
- 10.1177/2047487320908706
- ISSN
- 2047-4873
- Abstract
- Aims Previous studies from Western countries have been unable to demonstrate a relationship between insulin resistance and new-onset atrial fibrillation. We aimed to evaluate this relationship in the nondiabetic Asian population. Methods Between 2001-2003, 8175 adults (mean age 51.5 years, 53% women) without both existing atrial fibrillation and diabetes and with insulin resistance measures at baseline were enrolled and were followed by biennial electrocardiograms thereafter until 2014. We constructed multivariable-adjusted Cox proportional hazard models for risk of incident atrial fibrillation. Results Over a median follow-up of 12.3 years, 136 participants (1.89/1000 person-years) developed atrial fibrillation. Higher homeostasis model assessment of insulin resistance (HOMA-IR) was independently associated with newly developed atrial fibrillation (hazard ratio 1.61, 95% confidence interval 1.14-2.28). Atrial fibrillation development increased at the HOMA-IR levels approximately between 1-2.5, and then plateaued afterwards (p = 0.031). Conclusion There is a significant relationship between insulin resistance and atrial fibrillation development independent of other known risk factors, including obesity in a nondiabetic Asian population.
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