In SilicoAnalysis of the Antigenic Properties of Iron-Regulated Proteins againstNeisseria meningitidisopen access
- Authors
- Rahman, Shahedur; Biswas, Chayon; Biswas, Polash Kumar; Kader, Md Ashraful; Alam, S. M. Nur; Sonne, Christian; Kim, Ki-Hyun
- Issue Date
- Sep-2020
- Publisher
- MDPI
- Keywords
- Neisseria meningitidis; vaccine development; epidemic disease; immunogenicity
- Citation
- APPLIED SCIENCES-BASEL, v.10, no.17, pp.1 - 12
- Indexed
- SCIE
SCOPUS
- Journal Title
- APPLIED SCIENCES-BASEL
- Volume
- 10
- Number
- 17
- Start Page
- 1
- End Page
- 12
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/8951
- DOI
- 10.3390/app10176113
- ISSN
- 2076-3417
- Abstract
- Neisseria meningitidisis a commensal pathogen that causes infectious cerebrospinal disease in people of all ages. The multivariate role of six disease-causing polysaccharide serotypes is found to play a crucial role in developing vaccines (or general treatment strategies) to treat this emerging pathogen. Iron is a crucial transition metal forN. meningitidis. Proteomic analysis data could be valuable for vaccine design. Here, we conduct a comparative study using computational bioinformatic tools to identify the most effective iron-regulated outer membrane proteins (OMPs) as immunogenic targets for a potential vaccine againstN. meningitidis. The basic properties ofN. meningitidisOMPs are explored for flexibility, solubility, hydrophilicity, beta-turns, and overall antigenic probability. Results of our study suggest that iron-regulated OMPs are flexible and soluble in water with high densities of conformational B-cell epitopes. As such, they can be recommended as a novel candidate for a vaccine againstN. meningitidisbothin vitroandin vivo.
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