Ten-year trends in antibiotic usage at a tertiary care hospital in Korea, 2004 to 2013open access
- Authors
- Kim, Bongyoung; Hwang, Hyeonjun; Kim, Jieun; Lee, Myoung-jae; Pai, Hyunjoo
- Issue Date
- May-2020
- Publisher
- KOREAN ASSOC INTERNAL MEDICINE
- Keywords
- Anti-bacterial agents; Hospitals; Korea
- Citation
- KOREAN JOURNAL OF INTERNAL MEDICINE, v.35, no.3, pp.703 - 713
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- KOREAN JOURNAL OF INTERNAL MEDICINE
- Volume
- 35
- Number
- 3
- Start Page
- 703
- End Page
- 713
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/9867
- DOI
- 10.3904/kjim.2017.332
- ISSN
- 1226-3303
- Abstract
- Background/Aims: This study was performed to evaluate trends in antibiotic usage at a tertiary care hospital in Korea.
Methods: This study collated antibiotic prescription data and total patient days for inpatients at a tertiary care hospital in Korea between 2004 and 2013. The consumption of each class of antibiotic was converted to defined daily dose (DDD)/1.,000 patient-days. We defined 3rd generation cephalosporins, 4th generation cephalosporins, beta-lactam/beta-lactamase inhibitors, and fluoroquinolones as broad-spectrum antibiotics; carbapenems, tigecycline, glycopeptides, oxazolidinone, and polymyxin were defined as antibiotics against multidrug-resistant (MDR) pathogens. Other antibiotic classes were defined as nonbroad-spectrum antibiotics.
Results: Mean antibiotic consumption was 920.69 DDD/1,000 patient-days. The proportions of broad-spectrum antibiotics, antibiotics against MDR pathogens, and nonbroad-spectrum antibiotics were 41.8% (384.48/920.69), 3.5% (32.24/920.69), and 54.7% (503.97/920.69), respectively. Consumption of broad-spectrum antibiotics (coefficient for time 0.141; p = 0.049) and antibiotics against MDR pathogens (coefficient for time 0.185; p < 0.001) showed a significant increasing trend over the study period. Nonbroad-spectrum antibiotic consumption showed a significant decreasing trend over the study period (coefficient for time -2.601; p < 0.001).
Conclusions: Over the 10-year period, a stepwise increase in the consumption of broad-spectrum antibiotics and antibiotics against MDR pathogens was observed at a tertiary care hospital in Korea. Conversely, during the same period, nonbroad-spectrum antibiotic consumption showed a significant decreasing trend.
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