pH-Responsive Hydrogel Microparticles as Intelligent Delivery Carriers for alpha-MSH Antagonists
- Authors
- Yang, Juseung; Cho, Geundo; Lee, Tai-Gyu; Kim, Bumsang
- Issue Date
- Jul-2011
- Publisher
- WILEY-BLACKWELL
- Keywords
- hydrogel microparticles; pH-responsive; intelligent delivery system; alpha-MSH antagonists; skin permeability
- Citation
- AICHE JOURNAL, v.57, no.7, pp.1919 - 1925
- Journal Title
- AICHE JOURNAL
- Volume
- 57
- Number
- 7
- Start Page
- 1919
- End Page
- 1925
- URI
- https://scholarworks.bwise.kr/hongik/handle/2020.sw.hongik/19852
- DOI
- 10.1002/aic.12407
- ISSN
- 0001-1541
- Abstract
- For a first step in the development of an intelligent delivery system for a nonapeptide as an alpha-MSH antagonist, pH-responsive P(MAA-co-EGMA) hydrogel microparticles were prepared and their feasibility as intelligent delivery carriers was evaluated. There was a drastic change in the swelling ratio of P(MAA-co-EGMA) microparticles at a pH of around 5 and as the MAA amount in the hydrogel increased, the swelling ratio increased at a pH above 5. The loading efficiency of the nonapeptide at pH 7 increased with the amount of Methacrylic acid (MAA) in the hydrogel and at pH 2, where the electrostatic attraction was greatest, a high loading efficiency was not obtained because of the low swelling ratio of the hydrogel. The P(MAA-co-EGMA) microparticles demonstrated a pH-sensitive release behavior for the nonapeptide. In addition, the P(MAA-co-EGMA) microparticles showed a protective ability for the nonapeptide and preserved the stability of the nonapeptide. (C) 2010 American Institute of Chemical Engineers AIChE J, 57: 1919-1925, 2011
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