Detailed Information
Cited 0 time in 
Cited 0 time in 
Cited 0 time in
Metadata Downloads
Heparin-immobilized pluronic/PVA composite microparticles for the sustained delivery of ionic drug
- Authors
- Park, Hwa Young; Oh, Keun Sang; Koo, Hyoung Mo; Cho, Sun Hang; Chung, Sang Jun; Lim, Yong Taik; Kim, Dongmin; Yuk, Soon Hong
- Issue Date
- Mar-2008
- Publisher
- TAYLOR & FRANCIS LTD
- Keywords
- microparticle; pluronic; polyvinylalcohol; heparin; sustained release of ionic drug
- Citation
- JOURNAL OF MICROENCAPSULATION, v.25, no.2, pp.106 - 110
- Journal Title
- JOURNAL OF MICROENCAPSULATION
- Volume
- 25
- Number
- 2
- Start Page
- 106
- End Page
- 110
- ISSN
- 0265-2048
- Abstract
- Heparin-immobilized Pluronic (F-68)/Polyvinylalcohol (PVA) composite microparticles were designed and characterized for the sustained drug delivery of ionic drug. Venlafaxine, antidepressant medication, was used as a model drug. For the efficient loading of ionic drug, heparin was immobilized into F-68/PVA composite microparticles. Differential scanning calorimetry (DSC) was used to understand the intra/intermolecular interactions in the heparin-immobilized F-68/PVA composite gels containing model drug. For the application as a sustained drug delivery system, the loading amount and release pattern of loaded drug were measured using high performance liquid chromatography (HPLC).
- Files in This Item
- There are no files associated with this item.
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.