Hydrophilized poly(lactide-co-glycolide) nanospheres with poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) triblock copolymer
- Authors
- Kim, BK; Kim, D; Cho, SH; Yuk, SH
- Issue Date
- Nov-2004
- Publisher
- TAYLOR & FRANCIS LTD
- Keywords
- hydrophilized poly(lactide-co-glycolide) nanospheres; pluronics; tetraglycol; paclitaxel
- Citation
- JOURNAL OF MICROENCAPSULATION, v.21, no.7, pp.697 - 707
- Journal Title
- JOURNAL OF MICROENCAPSULATION
- Volume
- 21
- Number
- 7
- Start Page
- 697
- End Page
- 707
- URI
- https://scholarworks.bwise.kr/hongik/handle/2020.sw.hongik/25731
- DOI
- 10.1080/02652040400000520
- ISSN
- 0265-2048
- Abstract
- A novel method for preparing the PLGA nanospheres with hydrophilic surface has been designed and characterized. Because of good solubility of tetraglycol in water, PLGA (poly(lactide-co-glycolide)) nanospheres were formed by spraying the PLGA/tetraglycol solution into water. The size of PLGA nanospheres was manipulated by changing the concentration of PLGA/tetraglycol solution. Based on the hydrophobic interaction between PLGA and poly(propylene oxide) domain of F-127 (one of Pluronics, poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) triblock copolymer, F-127-coated PLGA nanospheres was prepared to enhance the stability of PLGA nanospheres in the aqueous media. For the application as a drug delivery vehicle, it was characterized by measuring the loading amount, the encapsulation efficiency and the release pattern of drug. Paclitaxel used as a potent anti-cancer drug was selected as a model drug.
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Collections - College of Science and Technology > Department of Electronic and Electrical Engineering > 1. Journal Articles
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