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Afzelin positively regulates melanogenesis through the p38 MAPK pathway

Authors
Jung, EunsunKim, Jin HeeKim, Mi OkJang, SungheeKang, MingyeongOh, Sae WoongNho, Youn HwaKang, Seung HyunKim, Min HeePark, See-HyoungLee, Jongsung
Issue Date
25-Jul-2016
Publisher
ELSEVIER IRELAND LTD
Keywords
Afzelin; Melanogenesis; p38MAPK; MITF; TRP-1
Citation
CHEMICO-BIOLOGICAL INTERACTIONS, v.254, pp.167 - 172
Journal Title
CHEMICO-BIOLOGICAL INTERACTIONS
Volume
254
Start Page
167
End Page
172
URI
https://scholarworks.bwise.kr/hongik/handle/2020.sw.hongik/7561
DOI
10.1016/j.cbi.2016.06.010
ISSN
0009-2797
Abstract
Melanogenesis refers to synthesis of the skin pigment melanin, which plays a critical role in the protection of skin against ultraviolet irradiation and oxidative stressors. We investigated the effects of afzelin on melanogenesis and its mechanisms of action in human epidermal melanocytes. In this study, we found that afzelin increased both melanin content and tyrosinase activity in a concentration-dependent manner. While the mRNA levels of microphthalmia-associated transcription factor (MITF), tyrosinase, and tyrosinase-related protein (TRP)-1 increased following afzelin treatment, the mRNA levels of TRP-2 were not affected by afzelin. Likewise, afzelin increased the protein levels of MITF, TRP-1, and tyrosinase but not TRP-2. Mechanistically, we found that afzelin regulated melanogenesis by upregulating MITF through phosphorylation of p38 mitogen-activated protein kinase (MAPK), independent of cyclic adenosine monophosphate (cAMP)-protein kinase A (PKA) signaling. Taken together, these findings indicate that the promotion of melanogenesis by afzelin occurs through increased MITF gene expression, which is mediated by activation of p38 MAPK, and suggest that afzelin may be useful as a protective agent against ultraviolet irradiation. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
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