Surface Functionalized Graphene Biosensor on Sapphire for Cancer Cell Detection
- Authors
- Joe, Daniel J.; Hwang, Jeonghyun; Johnson, Christelle; Cha, Ho-Young; Lee, Jo-Won; Shen, Xiling; Spencer, Michael G.; Tiwari, Sandip; Kim, Moonkyung
- Issue Date
- Jan-2016
- Publisher
- AMER SCIENTIFIC PUBLISHERS
- Keywords
- Biosensors; Graphene; 2D; Cell Detection; CVD
- Citation
- JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, v.16, no.1, pp.144 - 151
- Journal Title
- JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
- Volume
- 16
- Number
- 1
- Start Page
- 144
- End Page
- 151
- URI
- https://scholarworks.bwise.kr/hongik/handle/2020.sw.hongik/8217
- DOI
- 10.1166/jnn.2016.12042
- ISSN
- 1533-4880
- Abstract
- Graphene has several unique physical, optical and electrical properties such as a two-dimensional (2D) planar structure, high optical transparency and high carrier mobility at room temperature. These make graphene interesting for electrical biosensing. Using a catalyst-free chemical vapor deposition (CVD) method, graphene film is grown on a sapphire substrate. There is a single or a few sheets as confirmed by Raman spectroscopy and atomic force microscopy (AFM). Electrical graphene biosensors are fabricated to detect large-sized biological analytes such as cancer cells. Human colorectal carcinoma cells are sensed by the resistance change of an active bio-functionalized graphene device as the cells are captured by the immobilized antibody surface. The functionalized sensors show an increase in resistance as large as similar to 20% of the baseline with a small number of adhered cells. This study suggests that the bio-functionalized electrical graphene sensors on sapphire, which is a highly transparent material, can potentially detect circulating tumor cells (CTCs) and monitor cellular electrical behavior while being compatible with fluorescence-based optical detection bioassays.
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Collections - College of Engineering > School of Electronic & Electrical Engineering > 1. Journal Articles
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