Chondroitin sulfate-based biomaterials for tissue engineering
- Authors
- Kwon, Hyuck Joon; Han, Youngbae
- Issue Date
- 2016
- Publisher
- TUBITAK SCIENTIFIC & TECHNICAL RESEARCH COUNCIL TURKEY
- Keywords
- Chondroitin sulfate; tissue engineering; regenerative medicine; scaffold; stem cell
- Citation
- TURKISH JOURNAL OF BIOLOGY, v.40, no.2, pp.290 - 299
- Journal Title
- TURKISH JOURNAL OF BIOLOGY
- Volume
- 40
- Number
- 2
- Start Page
- 290
- End Page
- 299
- URI
- https://scholarworks.bwise.kr/hongik/handle/2020.sw.hongik/8820
- DOI
- 10.3906/biy-1507-16
- ISSN
- 1300-0152
- Abstract
- Chondroitin sulfate (CS) is a sulfated glycosaminoglycan (GAG) that is usually found attached to proteins as part of a proteoglycan. The use of CS-based biomaterials in the field of tissue engineering applications has been intensively growing over the past decades because CS is a biopolymer with the major advantages of being biodegradable, biocompatible, easily available, and highly versatile. In vitro and in vivo studies have shown that CS-based biomaterials upregulate cartilage-specific gene expression in chondrocytes and mesenchymal stem cells and also support osteogenic differentiation by increasing the effectiveness of bone anabolic growth factors. Chondroitin sulfate proteoglycan plays a key role during the acute recovery stage after spinal cord injury by activating microglia/macrophages and modulating neurotrophic factor secretion. In addition, CS-based materials promote the wound-healing process and stimulate the regeneration of skin defects. Moreover, CS can be used to construct high toughness gels by having a double network structure. Taken together, CS-based biomaterials would be a useful material for successful replacement and regeneration of damaged cartilage, bone, skin, and neural tissues.
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