Tumor-suppressive activity of 1,25-dihydroxyvitamin D3 against kidney cancer cells via up-regulation of FOXO3
- Authors
- Lee, Jongsung; Park, See-Hyoung
- Issue Date
- 2016
- Publisher
- TAYLOR & FRANCIS LTD
- Keywords
- tumor-suppressive; 1; 25-dihydroxyvitamin D3; kidney; cancer; FOXO3
- Citation
- BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, v.80, no.10, pp.1947 - 1953
- Journal Title
- BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
- Volume
- 80
- Number
- 10
- Start Page
- 1947
- End Page
- 1953
- URI
- https://scholarworks.bwise.kr/hongik/handle/2020.sw.hongik/8839
- DOI
- 10.1080/09168451.2016.1184561
- ISSN
- 0916-8451
- Abstract
- 1,25-Dihydroxyvitamin D3 has been known to have the tumor-suppressive activity in various kinds of tumors. However, the exact effect and working mechanism of 1,25-dihydroxyvitamin D3 on the tumor-suppressive activity in human kidney cancer cells remains poorly understood. 1,25-Dihydroxyvitamin D3 has cytotoxicity to ACHN cells and inhibited ACHN cell proliferation compared to the vehicle control. 1,25-Dihydroxyvitamin D3 increased the expression of the cleaved PARP1, active Caspase3, Bax, and Bim but decreased the expression of Bcl2 in ACHN cells. Moreover, 1,25-dihydroxyvitamin D3 down-regulated the phosphorylated Akt and Erk which might lead to apoptosis through activation of FOXO3 in ACHN cells. Transfection of siRNA against FOXO3 attenuated the pro-apoptotic BimEL expression in ACHN cells treated with 1,25-dihydroxyvitamin D3. These results suggest that FOXO3 is involved in the apoptosis induced by 1,25-dihydroxyvitamin D3.
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Collections - College of Science and Technology > Department of Biological and Chemical Engineering > 1. Journal Articles
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