독활의 항혈소판 및 항산화 효과Effects of Aralia continentalis Kitagawa on Antiplatelet and Antioxidative Activities
- Other Titles
- Effects of Aralia continentalis Kitagawa on Antiplatelet and Antioxidative Activities
- Authors
- 양선아; 임남경; 지광환; 이인선
- Issue Date
- 2008
- Publisher
- 한국생명과학회
- Keywords
- Aralia continentalis Kitagawa; platelet aggregation; platelet adhesion; antioxidant
- Citation
- 생명과학회지, v.18, no.3, pp.357 - 362
- Journal Title
- 생명과학회지
- Volume
- 18
- Number
- 3
- Start Page
- 357
- End Page
- 362
- URI
- https://scholarworks.bwise.kr/kumoh/handle/2020.sw.kumoh/17991
- ISSN
- 1225-9918
- Abstract
- The dried roots of Aralia continentalis Kitagawa is known to have the potential for anti-inflammation and anti-rheumatic, but their effects on thrombosis are not clear. In this study, we evaluated the anti-platelet and antioxidative activities of A. continentalis Kitagawa. Methanol extract and its various fractions of A. continentalis Kitagawa inhibited ADP-induced platelet aggregation, and EtOAc fraction showed strongest inhibition in a concentration-dependent manner with a IC50 value of 217.7 μg/ml. Moreover, the EtOAc fraction contained 77.7% of 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 43.1% of 2,2’-azinobis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical-scavenging activity at 0.1 mg/ml. In addition, the methanol and EtOAc fraction dose-dependently inhibited thrombin-stimulated platelet adhesion to collagen or fibrinogen. Collectively, these results suggest that the polyphenol-rich EtOAc fraction from A. continentalis Kitagawa can reduce platelet hyperactivation by scavenging free radicals. Thus, the EtOAc fraction of A. continentalis Kitagawa is a potential source for inhibition of platelet-dependent thrombosis.
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