Gold Nanocage-Incorporated Poly(epsilon-Caprolactone) (PCL) Fibers for Chemophotothermal Synergistic Cancer Therapy
- Authors
- Park, Ju Hyang; Seo, Hojun; Kim, Da In; Choi, Ji Hyun; Son, Jin Ho; Kim, Jongbok; Moon, Geon Dae; Hyun, Dong Choon
- Issue Date
- Feb-2019
- Publisher
- MDPI
- Keywords
- PCL; electrospinning; combination therapy; photothermal therapy; NIR-triggered drug release
- Citation
- PHARMACEUTICS, v.11, no.2
- Journal Title
- PHARMACEUTICS
- Volume
- 11
- Number
- 2
- URI
- https://scholarworks.bwise.kr/kumoh/handle/2020.sw.kumoh/199
- DOI
- 10.3390/pharmaceutics11020060
- ISSN
- 1999-4923
- Abstract
- This paper introduces a new fibrous system for synergistic cancer therapy, which consists of gold nanocage (AuNC)-loaded poly(epsilon-caprolactone) (PCL) fibers with encapsulation of a chemotherapeutic anticancer drug in their core and loading of a phase-changeable fatty acid in their sheath. Under on-off switching of near-infrared (NIR) light irradiation, the excellent photothermal ability and photostability of AuNCs allows repeated, significant heating of the fibers to a temperature available to hyperthermia. Simultaneously, the NIR light-induced heat generation enables the melting out of the loaded fatty acid, leading to a rapid release of the drug molecules from the fibers. The combination of this NIR light-triggered drug release with the repeated hyperthermia treatment exhibits excellent anticancer efficacy.
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Collections - Department of Materials Science and Engineering > 1. Journal Articles
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