Promoting bone regeneration by 3D-printed poly(glycolic acid)/hydroxyapatite composite scaffolds
- Authors
- Yeo, Taegyun; Ko, Young-Gwang; Kim, Eun Jin; Kwon, Oh Kyoung; Chung, Ho Yun; Kwon, Oh Hyeong
- Issue Date
- 25-Feb-2021
- Publisher
- ELSEVIER SCIENCE INC
- Keywords
- Hydroxyapatite; Poly(glycolic acid); 3D printing; Scaffold; Tissue engineering
- Citation
- JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY, v.94, pp.343 - 351
- Journal Title
- JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
- Volume
- 94
- Start Page
- 343
- End Page
- 351
- URI
- https://scholarworks.bwise.kr/kumoh/handle/2020.sw.kumoh/20824
- DOI
- 10.1016/j.jiec.2020.11.004
- ISSN
- 1226-086X
- Abstract
- Hydroxyapatite (HAp) is a major bone graft component for hard tissue regeneration. However, sintered HAp has poor formability and mechanical properties. Porous 3D scaffolds for bone tissue regeneration were printed with computer-aided modeling using poly(glycolic acid) (PGA) and HAp. PGA scaffolds containing HAp nanoparticles were fabricated with a 400 mu m pore size. PGA/HAp scaffolds containing 12.5 wt% HAp showed considerable compressive strength, osteogenesis, mineralization, and biodegradation. In in vivo animal experiments, the PGA/HAp group exhibited 47% bone regeneration, with superior bone mineral density 8 weeks after surgery. 3D-printed PGA/HAp scaffolds could provide a feasible option to promote patient-specific bone regeneration. (C) 2020 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.
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