Biodegradable silicon nanoneedles for ocular drug deliveryopen access
- Authors
- Park, Woohyun; Van Phuc Nguyen; Jeon, Yale; Kim, Bongjoong; Li, Yanxiu; Yi, Jonghun; Kim, Hyungjun; Leem, Jung Woo; Kim, Young L.; Kim, Dong Rip; Paulus, Yannis M.; Lee, Chi Hwan
- Issue Date
- Apr-2022
- Publisher
- AMER ASSOC ADVANCEMENT SCIENCE
- Citation
- SCIENCE ADVANCES, v.8, no.13
- Journal Title
- SCIENCE ADVANCES
- Volume
- 8
- Number
- 13
- URI
- https://scholarworks.bwise.kr/kumoh/handle/2020.sw.kumoh/21095
- DOI
- 10.1126/sciadv.abn1772
- ISSN
- 2375-2548
- Abstract
- Ocular drug delivery remains a grand challenge due to the complex structure of the eye. Here, we introduce a unique platform of ocular drug delivery through the integration of silicon nanoneedles with a tear-soluble contact lens. The silicon nanoneedles can penetrate into the cornea in a minimally invasive manner and then undergo gradual degradation over the course of months, enabling painless and long-term sustained delivery of ocular drugs. The tear-soluble contact lens can fit a variety of corneal sizes and then quickly dissolve in tear fluid within a minute, enabling an initial burst release of anti-inflammatory drugs. We demonstrated the utility of this platform in effectively treating a chronic ocular disease, such as corneal neovascularization, in a rabbit model without showing a notable side effect over current standard therapies. This platform could also be useful in treating other chronic ocular diseases.
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- Appears in
Collections - Department of Applied Chemistry > 1. Journal Articles
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