Late paradoxical lymph node enlargement during and after anti-tuberculosis treatment in non-HIV-infected patients
- Authors
- Yu, S. N.; Cho, O-H.; Park, K-H.; Jung, J.; Kim, Y. K.; Lee, J. Y.; Chong, Y-P.; Lee, S-O.; Choi, S-H.; Kim, Y. S.; Woo, J. H.; Kim, S-H.
- Issue Date
- Nov-2015
- Publisher
- International Union Against Tuberculosis And Lung Disease/Union Internationale Contre la Tuberculose et les Maladies Respiratories
- Keywords
- tuberculosis; lymphadenopathy; paradoxical response
- Citation
- International Journal of Tuberculosis and Lung Disease, v.19, no.11, pp 1388 - 1394
- Pages
- 7
- Journal Title
- International Journal of Tuberculosis and Lung Disease
- Volume
- 19
- Number
- 11
- Start Page
- 1388
- End Page
- 1394
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/10169
- DOI
- 10.5588/ijtld.15.0257
- ISSN
- 1027-3719
1815-7920
- Abstract
- SETTINGS: A tertiary referral centre in South Korea. OBJECTIVE: To investigate the incidence, clinical characteristics and outcomes of late paradoxical response (>4 months after the initiation of anti-tuberculosis treatment) during and after anti-tuberculosis treatment in non-human immunodeficiency virus (HIV) infected patients with lymph node tuberculosis (TB). DESIGN: We retrospectively reviewed the medical records of non-HIV-infected patients with lymph node TB between 1997 and 2007, and prospectively enrolled patients with newly diagnosed lymph node TB between 2008 and 2013. RESULTS: Of 467 patients with confirmed and probable lymph node TB, 83 (18%) displayed a paradoxical response: 57 of these (69%) were classified as early and 26 (31%) as late paradoxical response. Patients with late paradoxical response (median 12 months) received more prolonged anti-tuberculosis treatment than those with early (median 9 months, P < 0.001) or no paradoxical response (median 9 months, P < 0.001). The frequency of post-treatment lymph node enlargement increased progressively from those without any paradoxical response (6%), through those with an early response (12%) to those with a late response (23%). CONCLUSIONS: Paradoxical response presents late in about one third of non-HIV-infected patients with lymph node TB who experience a response. Although anti-tuberculosis treatment is commonly prolonged in patients with late paradoxical response, post-treatment lymph node enlargement is more frequent in these patients.
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Collections - College of Medicine > Department of Internal Medicine > 1. Journal Articles
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