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Eupartoium makinoi suppresses lipopolysaccharide-induced inducible nitric oxide synthase and cyclooxygenase-2 expression
- Authors
- Ahn, Sang-Il; Lim, Se Jin; Gu, Gyo-Jeong; Kim, Ji-Soo; Paek, Ji Hun; Kim, Songmun; Lim, Soon Sung; Youn, Hyung-Sun
- Issue Date
- 4-Jul-2015
- Publisher
- Taylor & Francis
- Keywords
- Eupatorium makinoi; cyclooxygenase-2; lipopolysaccharide; inducible nitric oxide synthase; nuclear factor-kappa B
- Citation
- Food and Agricultural Immunology, v.26, no.4, pp 496 - 503
- Pages
- 8
- Journal Title
- Food and Agricultural Immunology
- Volume
- 26
- Number
- 4
- Start Page
- 496
- End Page
- 503
- ISSN
- 0954-0105
1465-3443
- Abstract
- Inflammation is involved in numerous diseases including cancer. Inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) play important roles in the development of certain inflammatory diseases. Eupatorium makinoi, which belongs to a family of Asteraceae plants, is used medicinally in East Asia. We investigated the effects of an ethanol extract of E. makinoi (EEM) on nuclear factor-kappa B (NF-kappa B) activation and the expression of iNOS and COX-2 with lipopolysaccharide (TLR4 agonist) in murine macrophages. EEM suppressed NF-kappa B activation and iNOS and COX-2 expression induced by LPS. These results suggest that EEM may regulate TLR4 signalling pathways and this may be a useful strategy for anti-inflammatory therapies.
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Related Researcher
- youn, hyung sun
- College of Medical Sciences (Department of Biomedical Laboratory Science)