CD8 alpha(-) Dendritic Cells Induce Antigen-Specific T Follicular Helper Cells Generating Efficient Humoral Immune Responses
- Authors
- Shin, Changsik; Han, Jae-A; Koh, Hyein; Choi, Bongseo; Cho, Yongbin; Jeong, Hyeongmin; Ra, Jea-Sun; Sung, Pil Soo; Shin, Eui-Cheol; Ryu, Seongho; Do, Yoonkyung
- Issue Date
- 30-Jun-2015
- Publisher
- Cell Press
- Keywords
- Dendritic cell; immunology; follicular helper T cell
- Citation
- Cell Reports, v.11, no.12, pp 1929 - 1940
- Pages
- 12
- Journal Title
- Cell Reports
- Volume
- 11
- Number
- 12
- Start Page
- 1929
- End Page
- 1940
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/10542
- DOI
- 10.1016/j.celrep.2015.05.042
- ISSN
- 2211-1247
- Abstract
- Recent studies on T follicular helper (Tfh) cells have significantly advanced our understanding of T cell-dependent B cell responses. However, little is known about the early stage of Tfh cell commitment by dendritic cells (DCs), particularly by the conventional CD8 alpha(+) and CD8 alpha(-) DC subsets. We show that CD8 alpha(-) DCs localized at the interfollicular zone play a pivotal role in the induction of antigen-specific Tfh cells by upregulating the expression of Icosl and Ox40l through the non-canonical NF-kappa B signaling pathway. Tfh cells induced by CD8 alpha(-) DCs function as true B cell helpers, resulting in significantly increased humoral immune responses against various human pathogenic antigens, including Yersinia pestis LcrV, HIV Gag, and hepatitis B surface antigen. Our findings uncover a mechanistic role of CD8 alpha(-) DCs in the initiation of Tfh cell differentiation and thereby provide a rationale for investigating CD8 alpha(-) DCs in enhancing antigen-specific humoral immune responses for improving vaccines and therapeutics.
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Collections - Graduate School > Department of Integrated Biomedical Science > 1. Journal Articles
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