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The effect of combination treatment using palonosetron and dexamethasone for the prevention of postoperative nausea and vomiting versus dexamethasone alone in women receiving intravenous patient-controlled analgesia

Authors
Ryoo, Seung-hwaYoo, Jae HwaKim, Mun GyuLee, Ki HoonKim, Soon Im
Issue Date
Jun-2015
Publisher
대한마취통증의학회
Keywords
Dexamethasone; Palonosetron; Postoperative nausea and vomiting
Citation
Korean Journal of Anesthesiology, v.68, no.3, pp 267 - 273
Pages
7
Journal Title
Korean Journal of Anesthesiology
Volume
68
Number
3
Start Page
267
End Page
273
URI
https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/10619
DOI
10.4097/kjae.2015.68.3.267
ISSN
2005-6419
2005-7563
Abstract
Background: The purpose of this study was to evaluate the effect of palonosetron combined with dexamethasone for the prevention of PONV compared to dexamethasone alone in women who received intravenous patient-controlled analgesia (IV-PCA) using fentanyl. Methods: In this randomized, double-blinded, placebo-controlled study, 204 healthy female patients who were scheduled to undergo elective surgery under general anesthesia followed by IV-PCA for postoperative pain control were enrolled. Patients were divided into two groups: the PD group (palonosetron 0.075 mg and dexamethasone 5 mg IV; n = 102) and the D group (dexamethasone 5 mg IV; n = 102). The treatments were given after the induction of anesthesia. The incidence of nausea, vomiting, severity of nausea, and the use of rescue anti-emetics during the first 48 hours after surgery were evaluated. Results: The incidence of PONV was significantly lower in the PD group compared with the D group during the 0-24 hours (43 vs. 59%) and 0-48 hours after surgery (45 vs. 63%) (P < 0.05). The severity of nausea during the 6- 24 hours after surgery was significantly less in the PD group compared with the D group (P < 0.05). The incidence of rescue antiemetic used was significantly lower in the PD group than in the D group during the 0-6 hours after surgery (13.1 vs. 24.5%) (P < 0.05). Conclusions: Palonosetron combined with dexamethasone was more effective in preventing PONV compared to dexamethasone alone in women receiving IV-PCA using fentanyl.
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