Statin eligibility and cardiovascular risk burden assessed by coronary artery calcium score: Comparing the two guidelines in a large Korean cohort
- Authors
- Rhee, Eun-Jung; Park, Se Eun; Oh, Hyung Geun; Park, Cheol-Young; Oh, Ki-Won; Park, Sung-Woo; Blankstein, Ron; Plutzky, Jorge; Lee, Won-Young
- Issue Date
- May-2015
- Publisher
- Elsevier BV
- Keywords
- Atherosclerosis; Coronary artery calcification (CAC); Statin; Pooled Cohort Equation
- Citation
- Atherosclerosis, v.240, no.1, pp 242 - 249
- Pages
- 8
- Journal Title
- Atherosclerosis
- Volume
- 240
- Number
- 1
- Start Page
- 242
- End Page
- 249
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/10701
- DOI
- 10.1016/j.atherosclerosis.2015.03.006
- ISSN
- 0021-9150
1879-1484
- Abstract
- Objective: To investigate the statin eligibility and the predictabilities for cardiovascular disease between AHA/ACC and ATPIII guidelines, comparing those results to concomitant coronary artery calcium scores (CACS) in a large cohort of Korean individuals who met statin-eligibility criteria. Methods: Among 19,920 participants in a health screening program, eligibility for statin treatment was assessed by the two guidelines. The presence and extent of coronary artery calcification (CAC) was measured by multi-detector computed tomography and compared among the various groups defined by the two guidelines. Results: Applying the new ACC/AHA guideline to the health screening cohort increased the statin-eligible population from 18.7% (as defined by ATP III) to 21.7%. Statin-eligible subjects as defined only by ACC/AHA guideline manifested a higher proportion of subjects with CAC compared with those meeting only ATP-III criteria even after adjustment for age and sex (47.1 vs. 33.8%, p < 0.01). Statin-eligible subjects as defined by ACC/AHA guideline showed higher odds ratio for the presence of CACS > 0 compared with those meeting ATP-III criteria {3.493 (3.245 similar to 3.759) vs. 2.865 (2.653 similar to 3.094)}, which was attenuated after adjusted for age and sex. Conclusions: In this large Korean cohort, more subjects would have qualified for statin initiation under the new ACC/AHA guideline as compared with the proportion recommended for statin treatment by ATP III guideline. Among statin-eligible Korean health screening subjects, the new ACC/AHA guideline identified a greater extent of atherosclerosis as assessed by CACS as compared to ATP III guideline assessment. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
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Collections - College of Medicine > Department of Neurology > 1. Journal Articles
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