Association of restrictive ventilatory dysfunction with the development of prediabetes and type 2 diabetes in Koreans
- Authors
- Kim, Chul-Hee; Kim, Hong-Kyu; Kim, Eun-Hee; Bae, Sung-Jin; Jung, Young-Ju; Choi, Jaewon; Park, Joong-Yeol
- Issue Date
- Apr-2015
- Publisher
- Springer Verlag
- Keywords
- Pulmonary function; Restrictive ventilatory dysfunction; Prediabetes; Type 2 diabetes mellitus
- Citation
- Acta Diabetologica, v.52, no.2, pp 357 - 363
- Pages
- 7
- Journal Title
- Acta Diabetologica
- Volume
- 52
- Number
- 2
- Start Page
- 357
- End Page
- 363
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/10766
- DOI
- 10.1007/s00592-014-0649-0
- ISSN
- 0940-5429
1432-5233
- Abstract
- This study was performed to investigate whether ventilatory dysfunction is a predictor for the development of prediabetes and type 2 diabetes in Koreans. We analyzed the clinical and laboratory data of 16,195 Korean adults (age 20-79 years) who underwent routine medical checkups with a mean 4.7-years (range 3.0-5.9 years) interval. Spirometry results were categorized into three patterns: normal, obstructive ventilatory dysfunction [OVD; forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) < 0.70], and restrictive ventilatory dysfunction (RVD; FVC < 80 % predicted, FEV1/FVC a parts per thousand yen 0.70). Compared with subjects with normal ventilatory function, subjects with RVD had a higher incidence of type 2 diabetes (3.7 vs. 6.3 %; P < 0.001), whereas subjects with OVD did not (3.7 vs. 4.8 %; P = 0.119). On multivariate logistic regression analysis, the odds ratio (OR) of RVD for type 2 diabetes was significantly increased after adjusting for age, sex, and lifestyle factors (1.40; 95 % CI 1.10-1.78). However, further adjustment for body mass index (BMI), waist circumference, and baseline glucose level attenuated the OR to become insignificant (1.12; 95 % CI 0.86-1.47). Among the 9,461 participants who had normal fasting glucose and HbA1c levels at baseline, the OR for progression to prediabetes or diabetes in the RVD group was significantly increased (1.30; 95 % CI 1.12-1.51). The increased OR remained significant after adjusting for BMI, waist circumference, and baseline glucose level (1.26; 95 % CI 1.07-1.47). Our results indicate that restrictive, but not obstructive ventilatory dysfunction, is independently associated with development of prediabetes and precedes the development of type 2 diabetes.
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