Association of nasal inflammation and lower airway responsiveness in schoolchildren based on an epidemiological survey
- Authors
- Myung, Jun-Ho; Seo, Hyun-Jeong; Park, Soo-Jeong; Kim, Bo-Young; Shin, Il-Sang; Jang, Jun-Hak; Kim, Yun-Kyung; Jang, An-Soo
- Issue Date
- Mar-2015
- Publisher
- 대한내과학회
- Keywords
- Eosinophils; Nose; Bronchial hyperreactivity
- Citation
- The Korean Journal of Internal Medicine, v.30, no.2, pp 226 - 231
- Pages
- 6
- Journal Title
- The Korean Journal of Internal Medicine
- Volume
- 30
- Number
- 2
- Start Page
- 226
- End Page
- 231
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/10833
- DOI
- 10.3904/kjim.2015.30.2.226
- ISSN
- 1226-3303
2005-6648
- Abstract
- Background/Aims: We sought to increase our understanding of the rhinitis-asthma relationship and improve strategies for the treatment of patients with these diseases. The aim of this study was to identify a connection between upper airway inflammation and lower airway responsiveness. Methods: We counted eosinophils on nasal smears, and performed spirometry, allergic skin tests, and methacholine challenge tests in 308 schoolchildren plus a questionnaire on respiratory symptoms. The methacholine concentration causing a 20% fall in forced expiratory volume in 1 second (PC20 < 25 mg/mL) was used as the threshold of bronchial hyperresponsiveness (BHR). Results: In total, 26% of subjects had positive nasal eosinophils on a smear, and 46.2% of subjects had BHR at < 25 mg/mL methacholine PC20. Nasal symptoms were higher in subjects with than without nasal eosinophils (p = 0.012). Asthma symptoms did not differ between subjects with and without nasal eosinophils. Nasal eosinophils were higher in subjects with atopy than those without (p = 0.006), and there was no difference in PC20 methacholine according to atopy (15.5 +/- 1.07 vs. 17.5 +/- 0.62; p > 0.05). No difference in BHR was detected when comparing subjects with and without nasal eosinophils. There were significant differences in the PC20 between subjects with greater than 50% nasal eosinophils and without nasal eosinophils (11.01 +/- 2.92 mg/mL vs. 17.38 +/- 0.61 mg/m.L; p < 0.004 Conclusions: These findings demonstrated that nasal eosinophilic inflammation might contribute to lower airway responsiveness in schoolchildren, based on an epidemiological survey.
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Collections - College of Medicine > Department of Internal Medicine > 1. Journal Articles
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