Neurons in the hippocampal CA1 region, but not the dentate gyrus, are susceptible to oxidative stress in rats with streptozotocin-induced type 1 diabetes
- Authors
- Lee, Sang Gun; Yoo, Dae Young; Jung, Hyo Young; Nam, Sung Min; Kim, Jong Whi; Choi, Jung Hoon; Yi, Sun Shin; Won, Moo-Ho; Yoon, Yeo Sung; Hwang, In Koo; Moon, Seung Myung
- Issue Date
- Mar-2015
- Publisher
- Neural Regeneration Research
- Keywords
- nerve regeneration; hippocampus; dentate gyrus; lipid peroxidation; type 1 diabetes; malondialdehyde; neurons; neural regeneration
- Citation
- Neural Regeneration Research, v.10, no.3, pp 451 - 456
- Pages
- 6
- Journal Title
- Neural Regeneration Research
- Volume
- 10
- Number
- 3
- Start Page
- 451
- End Page
- 456
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/10849
- DOI
- 10.4103/1673-5374.153695
- ISSN
- 1673-5374
1876-7958
- Abstract
- In this study, we investigated the effects of streptozotocin-induced type 1 diabetes on antioxidant-like protein-1 immunoreactivity, protein carbonyl levels, and malondialdehyde formation, a marker for lipid peroxidation, in the hippocampus. For this study, streptozotocin (75 mg/kg) was intraperitoneally injected into adult rats to induce type 1 diabetes. The three experimental parameters were determined at 2, 3, 4 weeks after streptozotocin treatment. Fasting blood glucose levels significantly increased by 20.7-21.9 mM after streptozotocin treatment. The number of antioxidant-like protein-1 immunoreactive neurons significantly decreased in the hippocampal CA1 region, but not the dentate gyrus, 3 weeks after streptozotocin treatment compared to the control group. Malondialdehyde and protein carbonyl levels, which are modified by oxidative stress, significantly increased with a peak at 3 weeks after malondialdehyde treatment, and then decreased 4 weeks after malondialdehyde treatment. These results suggest that neurons in the hippocampal CA1 region, but not the dentate gyrus, are susceptible to oxidative stress 3 weeks after malondialdehyde treatment.
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Collections - College of Medical Sciences > Department of Biomedical Laboratory Science > 1. Journal Articles
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