An MHC II-Dependent Activation Loop between Adipose Tissue Macrophages and CD4(+) T Cells Controls Obesity-Induced Inflammation
- Authors
- Cho, Kae Won; Morris, David L.; DelProposto, Jennifer L.; Geletka, Lynn; Zamarron, Brian; Martinez-Santibanez, Gabriel; Meyer, Kevin A.; Singer, Kanakadurga; O'Rourke, Robert W.; Lumeng, Carey N.
- Issue Date
- 23-Oct-2014
- Publisher
- Cell Press
- Keywords
- obesity; adipose tissue inflmammation; macrophage
- Citation
- Cell Reports, v.9, no.2, pp 605 - 617
- Pages
- 13
- Journal Title
- Cell Reports
- Volume
- 9
- Number
- 2
- Start Page
- 605
- End Page
- 617
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/11770
- DOI
- 10.1016/j.celrep.2014.09.004
- ISSN
- 2211-1247
- Abstract
- An adaptive immune response triggered by obesity is characterized by the activation of adipose tissue CD4(+) T cells by unclear mechanisms. We have examined whether interactions between adipose tissue macrophages (ATMs) and CD4(+) T cells contribute to adipose tissue metainflammation. Intravital microscopy identifies dynamic antigen-dependent interactions between ATMs and T cells in visceral fat. Mice deficient in major histocompatibility complex class II (MHC II) showed protection from diet-induced obesity. Deletion of MHC II expression in macrophages led to an adipose tissue-specific decrease in the effector/memory CD4(+) T cells, attenuation of CD11c(+) ATM accumulation, and improvement in glucose intolerance by increasing adipose tissue insulin sensitivity. Ablation experiments demonstrated that the maintenance of proliferating conventional T cells is dependent on signals from CD11c(+) ATMs in obese mice. These studies demonstrate the importance of MHCII-restricted signals from ATMs that regulate adipose tissue T cell maturation and metainflammation.
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Collections - Graduate School > Department of Integrated Biomedical Science > 1. Journal Articles
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