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Genetic association analysis of CNR1 and CNR2 polymorphisms with schizophrenia in a Korean population
- Authors
- Bae, Joon Seol; Kim, Jason Yongha; Park, Byung-Lae; Kim, Jeong-Hyun; Kim, Bomi; Park, Chul Soo; Kim, Bong-Jo; Lee, Cheol-Soon; Lee, Migyung; Choi, Woo Hyuk; Shin, Tae-Min; Hwang, Jaeuk; Shin, Hyoung Doo; Woo, Sung-Il
- Issue Date
- Oct-2014
- Publisher
- Lippincott Williams & Wilkins Ltd.
- Keywords
- CNR1; CNR2; schizophrenia; single-nucleotide polymorphism
- Citation
- Psychiatric Genetics, v.24, no.5, pp 225 - 229
- Pages
- 5
- Journal Title
- Psychiatric Genetics
- Volume
- 24
- Number
- 5
- Start Page
- 225
- End Page
- 229
- ISSN
- 0955-8829
1473-5873
- Abstract
- Located on 6q15 and 1p36.11, cannabinoid receptor 1 (CNR1) and cannabinoid receptor 2 (CNR2) genes are considered to be a positional and functional candidate gene for the development of mental disorders such as schizophrenia because CNR1 is known as a regulator of dopamine signaling in the hippocampus and the cerebral cortex. However, few genetic studies have been carried out to investigate an association of CNR1 and CNR2 polymorphisms and the risk of schizophrenia. In this study, although the result indicates that CNR1 and CNR2 variations are unlikely to influence schizophrenia susceptibility in a Korean population, the findings would provide meaningful information for further genetic studies. (C) 2014 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
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Related Researcher
- WOO, SUNG IL
- College of Medicine (Department of Psychiatry)