The role of wogonin in controlling SOCS3 expression in neuronal cells
- Authors
- Nam, Kung-Woo; Chae, Sungwook; Song, Ho-Yeon; Mar, Woongchon; Han, Man-Deuk
- Issue Date
- 8-Aug-2014
- Publisher
- Academic Press
- Keywords
- Wogonin; SOCS3; Neuroinflammation; PI3K; AP1; STAT3
- Citation
- Biochemical and Biophysical Research Communications, v.450, no.4, pp 1518 - 1524
- Pages
- 7
- Journal Title
- Biochemical and Biophysical Research Communications
- Volume
- 450
- Number
- 4
- Start Page
- 1518
- End Page
- 1524
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/11948
- DOI
- 10.1016/j.bbrc.2014.07.018
- ISSN
- 0006-291X
1090-2104
- Abstract
- The mechanism underlying the wogonin-mediated increase in the expression of suppressor of cytokine signaling 3 (SOCS3) is unclear. Promoter deletion assay results revealed that wogonin-induced SOCS3 expression is dependent on the AP-1 consensus sequences and two STAT responsive elements (TTACAAGAA and TTCCAGGAA) in the 5'-flanking region of the SOCS3 gene in SH-SY5Y cells. Wogonin-induced SOCS3 expression was blocked by inhibitors of PI3K, Akt, Raf, p38, JNK, MEK, and STAT3, respectively. However, JAK2 inhibitors did not inhibit wogonin-induced SOCS3 expression. These results indicate that SOCS3-inducing effect of wogonin is caused by the activation of PI3K-mediated MAPK signaling pathways (Akt, ERK1/2, p38, and JNK), and the subsequent activation of AP-1 consensus sequences and STAT responsive elements in SH-SY5Y cells. (C) 2014 Elsevier Inc. All rights reserved.
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