Association Analysis of Member RAS Oncogene Family Gene Polymorphisms with Aspirin Intolerance in Asthmatic Patients
- Authors
- Park, Jong-Sook; Heo, Jeong-Seok; Chang, Hun Soo; Choi, Inseon S.; Kim, Mi-Kyeong; Lee, Jong-Uk; Park, Byung Lae; Shin, Hyoung Doo; Park, Choon-Sik
- Issue Date
- 1-Mar-2014
- Publisher
- Mary Ann Liebert Inc.
- Citation
- DNA and Cell Biology, v.33, no.3, pp 155 - 161
- Pages
- 7
- Journal Title
- DNA and Cell Biology
- Volume
- 33
- Number
- 3
- Start Page
- 155
- End Page
- 161
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/12340
- DOI
- 10.1089/dna.2013.2213
- ISSN
- 1044-5498
1557-7430
- Abstract
- Member RAS oncogene family (RAB1A), a member of the RAS oncogene family, cycles between inactive GDP-bound and active GTP-bound forms regulating vesicle transport in exocytosis. Thus, functional alterations of the RAB1A gene may contribute to aspirin intolerance in asthmatic sufferers. To investigate the relationship between single-nucleotide polymorphisms (SNPs) in the RAB1A gene and aspirin-exacerbated respiratory disease (AERD), asthmatics (n=1197) were categorized into AERD and aspirin-tolerant asthma (ATA). All subjects were diagnosed as asthma on the basis of the Global Initiative for Asthma (GINA) guidelines. AERD was defined as asthmatics showing 15% or greater decreases in forced expiratory volume in one second (FEV1) or naso-ocular reactions by the oral acetyl salicylic acid (ASA) challenge (OAC) test. In total, eight SNPs were genotyped. Logistic regression analysis identified that the minor allele frequency of +14444 T>G and +41170 C>G was significantly higher in the AERD group (n=181) than in the ATA group (n=1016) (p=0.0003-0.03). Linear regression analysis revealed a strong association between the SNPs and the aspirin-induced decrease in FEV1 (p=0.0004-0.004). The RAB1A gene may play a role in the development of AERD in asthmatics and the genetic polymorphisms of the gene have the potential to be used as an indicator of this disease.
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Collections - College of Medicine > Soonchunhyang Institute of Medicine > 1. Journal Articles
- College of Medicine > Department of Internal Medicine > 1. Journal Articles
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