Pretreatment with recombinant human interleukin 2 (rhIL-2) Up-regulates PCNA-positive cells after partial hepatectomy in rat liver
- Authors
- Jeon, Miae; Kwon, Hyun Jung; Kim, Yong Hyun; Han, Kook-Il; Nam, Kung-Woo; Baik, Yeongjun; Lee, Sunghee; Kim, Wan-Jong; Han, Man-Deuk
- Issue Date
- Feb-2014
- Publisher
- 한국생물공학회
- Keywords
- rhIL-2; partial hepatectomy (PH); PCNA; immunohistochemistry; liver regeneration
- Citation
- Biotechnology and Bioprocess Engineering, v.19, no.1, pp 43 - 51
- Pages
- 9
- Journal Title
- Biotechnology and Bioprocess Engineering
- Volume
- 19
- Number
- 1
- Start Page
- 43
- End Page
- 51
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/12450
- DOI
- 10.1007/s12257-013-0667-8
- ISSN
- 1226-8372
1976-3816
- Abstract
- We prepared recombinant human interleukin-2 (rhIL-2) and studied its pretreated influence on liver regeneration and the blood profile in partially (67%) hepatectomized (PH) male Sprague-Dawley rats. Rats were injected in the tail vein with rhIL-2 three times per day for 3 consecutive days and 67% underwent a partial hepatectomy (PH). Five days after the PH, liver tissue and blood samples were analyzed for liver regeneration and hematological changes. The weight of the liver in the rhIL-2 pretreated groups increased in a dose-dependent manner; with the highest treatment (24 x 10(4) IU/kg), the maximum liver weight of 88.6% was exhibited. The control group showed a gradual increase to 76.3% of the original liver weight. A histological analysis of the liver showed an increase in proliferating cell nuclear antigen (PCNA)-positive cells in rhIL-2 pretreated rat livers. The rate of hepatocyte proliferation also increased significantly in primary cultured rat liver cells following rhIL-2 treatment. These results suggest that pretreatment with rhIL-2 may play adjuvant roles in liver regeneration after PH.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Natural Sciences > Department of Life Science and Biotechnology > 1. Journal Articles
- College of Natural Sciences > Department of Biology > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/12450)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.