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Pretreatment with recombinant human interleukin 2 (rhIL-2) Up-regulates PCNA-positive cells after partial hepatectomy in rat liver

Authors
Jeon, MiaeKwon, Hyun JungKim, Yong HyunHan, Kook-IlNam, Kung-WooBaik, YeongjunLee, SungheeKim, Wan-JongHan, Man-Deuk
Issue Date
Feb-2014
Publisher
한국생물공학회
Keywords
rhIL-2; partial hepatectomy (PH); PCNA; immunohistochemistry; liver regeneration
Citation
Biotechnology and Bioprocess Engineering, v.19, no.1, pp 43 - 51
Pages
9
Journal Title
Biotechnology and Bioprocess Engineering
Volume
19
Number
1
Start Page
43
End Page
51
URI
https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/12450
DOI
10.1007/s12257-013-0667-8
ISSN
1226-8372
1976-3816
Abstract
We prepared recombinant human interleukin-2 (rhIL-2) and studied its pretreated influence on liver regeneration and the blood profile in partially (67%) hepatectomized (PH) male Sprague-Dawley rats. Rats were injected in the tail vein with rhIL-2 three times per day for 3 consecutive days and 67% underwent a partial hepatectomy (PH). Five days after the PH, liver tissue and blood samples were analyzed for liver regeneration and hematological changes. The weight of the liver in the rhIL-2 pretreated groups increased in a dose-dependent manner; with the highest treatment (24 x 10(4) IU/kg), the maximum liver weight of 88.6% was exhibited. The control group showed a gradual increase to 76.3% of the original liver weight. A histological analysis of the liver showed an increase in proliferating cell nuclear antigen (PCNA)-positive cells in rhIL-2 pretreated rat livers. The rate of hepatocyte proliferation also increased significantly in primary cultured rat liver cells following rhIL-2 treatment. These results suggest that pretreatment with rhIL-2 may play adjuvant roles in liver regeneration after PH.
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