Bioassay-guided isolation and identification of anti-platelet-active compounds from the root of Ashitaba (Angelica keiskei Koidz.)
DC Field | Value | Language |
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dc.contributor.author | Son, Dong Ju | - |
dc.contributor.author | Park, Ye Oak | - |
dc.contributor.author | Yu, Chengguang | - |
dc.contributor.author | Lee, Sung Eun | - |
dc.contributor.author | Park, Young Hyun | - |
dc.date.accessioned | 2021-08-12T00:25:06Z | - |
dc.date.available | 2021-08-12T00:25:06Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 1478-6419 | - |
dc.identifier.issn | 1478-6427 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/13021 | - |
dc.description.abstract | Platelet aggregation is fundamental to a wide range of physiological and pathological processes, including the induction of thrombosis and arteriosclerosis. Anti-platelet activity of a crude methanol extract and solvent fractions of Ashitaba roots (Angelica keiskei Koidz.) was evaluated using a turbidimetric method using washed rabbit platelets. We identified the anti-platelet activities of two chalcones, 4-hydroxyderricin and xanthoangelol, isolated from the ethyl acetate-soluble fraction of Ashitaba roots by using a bioassay-guided isolation method. 4-Hydroxyderricin and xanthoangelol effectively inhibited platelet aggregation induced by collagen (IC50 of 41.9 and 35.9 mu M, respectively), platelet-activating factor (IC50 of 46.1 and 42.3 mu M, respectively) and phorbol 12-myristate 13-acetate (IC50 of 16.5 and 45.9 mu M, respectively). These compounds did not inhibit thrombin-induced platelet aggregation (IC50 of > 80 mu M). The results suggest that the chalcones 4-hydroxyderricin and xanthoangelol may be potent anti-thrombotic components of A. keiskei Koidz. | - |
dc.format.extent | 5 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Taylor & Francis | - |
dc.title | Bioassay-guided isolation and identification of anti-platelet-active compounds from the root of Ashitaba (Angelica keiskei Koidz.) | - |
dc.type | Article | - |
dc.publisher.location | 영국 | - |
dc.identifier.doi | 10.1080/14786419.2014.931389 | - |
dc.identifier.scopusid | 2-s2.0-84908663195 | - |
dc.identifier.wosid | 000342326700012 | - |
dc.identifier.bibliographicCitation | Natural Product Research, v.28, no.24, pp 2312 - 2316 | - |
dc.citation.title | Natural Product Research | - |
dc.citation.volume | 28 | - |
dc.citation.number | 24 | - |
dc.citation.startPage | 2312 | - |
dc.citation.endPage | 2316 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Applied | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.subject.keywordPlus | ANTIMETASTATIC ACTIVITIES | - |
dc.subject.keywordPlus | PRENYLATED CHALCONES | - |
dc.subject.keywordPlus | XANTHOANGELOL | - |
dc.subject.keywordPlus | 4-HYDROXYDERRICIN | - |
dc.subject.keywordPlus | RATS | - |
dc.subject.keywordPlus | ANTITUMOR | - |
dc.subject.keywordAuthor | Angelica keiskei Koidaz | - |
dc.subject.keywordAuthor | Ashitaba | - |
dc.subject.keywordAuthor | anti-platelet | - |
dc.subject.keywordAuthor | 4-hydroxyderricin | - |
dc.subject.keywordAuthor | xanthoangelol | - |
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